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• W2046379251 startingPage "1739" @default.
• W2046379251 abstract "Elucidation of the functional significance of the presence of acetylcholinesterase in spermatozoa was deferred until considerably after the initial observations that eserine increased flagellar beat frequency in Mytilus sperm (54). Discovered about forty years ago during surveys of seminal plasma constituents (2), the enzyme was later found to be associated with the particulate fraction (4). Even though characterized as a “true” acetylcholinesterase in the sperm flagellum (3), interpretations of the role of acetylcholine as a factor in motile processes remained speculative until a wide variety of cholinergic agents was found to affect sperm cell performance (32). Those agents which inhibit acetylcholine synthesis or block cholinergic receptors generally elicit a monophasic, inhibitory, dose-dependent response on sea urchin sperm swimming speed. These include hemicholinium, curare, α-bungarotoxin and decamethonium. Cholinomimetic substances and anticholinesterases (acetylcholine and nicotine; eserine, diisopropylfluorophosphate and neostigmine) act biphasically to increase the sperm swim rate at concentrations of 1 micromolar or less while higher concentrations slow or stop the forward motion of the sperm cells. Procaine (7), which competes with Ca2+ for cell surface binding sites, initially stimulates then completely inhinits sperm cell progression. Other substances which interfere with the cells′ access to Ca2+ or with the transport of Ca2+ into and within the cell adversely affect spermatozoan function. A conceptual model has been proposed, a) to relate the uptake of Ca2+ to cholinergic regulation of ionophoric channels through the sperm cell plasma membrane and b) for this Ca2+ to trigger release of sequestered calcium for coupling of excitation to flagellar wave propagation." @default.
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• W2046379251 date "1980-05-01" @default.
• W2046379251 modified "2023-09-23" @default.
• W2046379251 title "Sperm motility and calcium transport: A neurochemically controlled process" @default.
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• W2046379251 doi "https://doi.org/10.1016/0024-3205(80)90573-1" @default.
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