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- W2046382783 abstract "Although considerable research in recent years has focused on the transition from Mild Cognitive Impairment (MCI) to dementia, there is very little detailed study of the transition from normal cognition to MCI and dementia. We studied the transition from clearly intact memory and cognitive functioning to mild cognitive impairment of the amnestic type to very early dementia of the Alzheimer type (DAT) in a woman with a family history of DAT using annual evaluations with a comprehensive cognitive test battery over a 10-year period. The woman was 74 years old at the first evaluation and was 83 years old at the most recent evaluation. She has 18-years of education (master's degree in education) and is a retired high school biology teacher. The 3.5 hour test battery used in this study included the extended Alzheimer Disease Assessment Scale and additional tests of mental status, attention, new learning and memory, language, visuospatial functioning, and problem solving ability. The patient displayed average or better memory and cognition on all test measures using age norms at her first assessment at age 74. She subsequently displayed a gradually progressive decline on measures of new learning and memory (i.e., episodic memory) over the next ten years beginning with small declines on sensitive memory measures (e.g., 30-minute delayed recall on the Rey Auditory Verbal Learning Test) and resulting in severe impairment in episodic memory by age 78. A severe amnestic amnesia preceded any measurable decline on the non-memory measures. This case demonstrates that the progressive memory decline in DAT can occur gradually over seven or more years before there is any measurable impairment in non-memory cognitive functions even when a comprehensive neuropsychological battery is used to chart the course of decline in both memory and non-memory cognitive functioning. Further research is needed to study the transition from normal cognition to MCI to early dementia to determine how common (i.e., representative) this course of memory and cognitive decline is among patients with DAT and to describe other patterns and rates of memory and cognitive decline in other DAT patients." @default.
- W2046382783 created "2016-06-24" @default.
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- W2046382783 date "2005-07-01" @default.
- W2046382783 modified "2023-09-27" @default.
- W2046382783 title "[P-044]: Transition from normal cognition to amnestic MCI to DAT: A ten-year longitudinal case study with annual comprehensive cognitive assessments" @default.
- W2046382783 doi "https://doi.org/10.1016/j.jalz.2005.06.106" @default.
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