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- W2046391775 abstract "We present the first monolithically integrated silicon/glass liquid chromatography-electrospray ionization microchip for mass spectrometry. The microchip is fabricated by bonding a silicon wafer, which has deep reactive ion etched micropillar-filled channels, together with a glass lid. Both the silicon channel and the glass lid have a through-wafer etched sharp tip that produces a stable electrospray. The microchip is also compatible with laser induced fluorescence (LIF) detection, due to the glass lid. Separation of drugs in less than 5 minutes using either SiO(2) (normal phase) or C(18) coated (reversed-phase) pillars with good sensitivity was demonstrated with mass spectrometric detection as well as separation of fluorescent compounds with LIF detection." @default.
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- W2046391775 date "2012-01-01" @default.
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- W2046391775 title "A microfabricated micropillar liquid chromatographic chip monolithically integrated with an electrospray ionization tip" @default.
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- W2046391775 doi "https://doi.org/10.1039/c1lc20874h" @default.
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