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- W2046392024 endingPage "e40625" @default.
- W2046392024 startingPage "e40625" @default.
- W2046392024 abstract "Background There is accumulating evidence that anxiety impairs sleep. However, due to high sleep variability in anxiety disorders, it has been difficult to state particular changes in sleep parameters caused by anxiety. Sleep profiling in an animal model with extremely high vs. low levels of trait anxiety might serve to further define sleep patterns associated with this psychopathology. Methodology/Principal Findings Sleep-wake behavior in mouse lines with high (HAB), low (LAB) and normal (NAB) anxiety-related behaviors was monitored for 24 h during baseline and recovery after 6 h sleep deprivation (SD). The amounts of each vigilance state, sleep architecture, and EEG spectral variations were compared between the mouse lines. In comparison to NAB mice, HAB mice slept more and exhibited consistently increased delta power during non-rapid eye movement (NREM) sleep. Their sleep patterns were characterized by heavy fragmentation, reduced maintenance of wakefulness, and frequent intrusions of rapid eye movement (REM) sleep. In contrast, LAB mice showed a robust sleep-wake rhythm with remarkably prolonged sleep latency and a long, persistent period of wakefulness. In addition, the accumulation of delta power after SD was impaired in the LAB line, as compared to HAB mice. Conclusions/Significance Sleep-wake patterns were significantly different between HAB and LAB mice, indicating that the genetic predisposition to extremes in trait anxiety leaves a biological scar on sleep quality. The enhanced sleep demand observed in HAB mice, with a strong drive toward REM sleep, may resemble a unique phenotype reflecting not only elevated anxiety but also a depression-like attribute." @default.
- W2046392024 created "2016-06-24" @default.
- W2046392024 creator A5005874437 @default.
- W2046392024 creator A5020677641 @default.
- W2046392024 creator A5023995258 @default.
- W2046392024 creator A5064857788 @default.
- W2046392024 date "2012-07-11" @default.
- W2046392024 modified "2023-09-25" @default.
- W2046392024 title "Sleep Phenotyping in a Mouse Model of Extreme Trait Anxiety" @default.
- W2046392024 cites W1427890859 @default.
- W2046392024 cites W1529195928 @default.
- W2046392024 cites W1555810878 @default.
- W2046392024 cites W1588621455 @default.
- W2046392024 cites W161631919 @default.
- W2046392024 cites W1963859198 @default.
- W2046392024 cites W1966479610 @default.
- W2046392024 cites W1967583949 @default.
- W2046392024 cites W1970247745 @default.
- W2046392024 cites W1970682202 @default.
- W2046392024 cites W1973769351 @default.
- W2046392024 cites W1975928460 @default.
- W2046392024 cites W1978626522 @default.
- W2046392024 cites W1982568751 @default.
- W2046392024 cites W1983770667 @default.
- W2046392024 cites W1984163532 @default.
- W2046392024 cites W1984417371 @default.
- W2046392024 cites W1984524952 @default.
- W2046392024 cites W1984796397 @default.
- W2046392024 cites W1985924246 @default.
- W2046392024 cites W1986347544 @default.
- W2046392024 cites W1989385052 @default.
- W2046392024 cites W1989459627 @default.
- W2046392024 cites W1989889970 @default.
- W2046392024 cites W1992644509 @default.
- W2046392024 cites W1994117530 @default.
- W2046392024 cites W1995523543 @default.
- W2046392024 cites W2002281825 @default.
- W2046392024 cites W2007651172 @default.
- W2046392024 cites W2008371765 @default.
- W2046392024 cites W2012336724 @default.
- W2046392024 cites W2013042216 @default.
- W2046392024 cites W2013987967 @default.
- W2046392024 cites W2015417570 @default.
- W2046392024 cites W2015497232 @default.
- W2046392024 cites W2016306810 @default.
- W2046392024 cites W2016883776 @default.
- W2046392024 cites W2018144456 @default.
- W2046392024 cites W2021918466 @default.
- W2046392024 cites W2034583647 @default.
- W2046392024 cites W2038642707 @default.
- W2046392024 cites W2038664453 @default.
- W2046392024 cites W2040174390 @default.
- W2046392024 cites W2040409809 @default.
- W2046392024 cites W2041249958 @default.
- W2046392024 cites W2043625816 @default.
- W2046392024 cites W2045104861 @default.
- W2046392024 cites W2049479975 @default.
- W2046392024 cites W2049637545 @default.
- W2046392024 cites W2052650419 @default.
- W2046392024 cites W2058978561 @default.
- W2046392024 cites W2063449944 @default.
- W2046392024 cites W2065060780 @default.
- W2046392024 cites W2067101252 @default.
- W2046392024 cites W2067846778 @default.
- W2046392024 cites W2071151408 @default.
- W2046392024 cites W2071370203 @default.
- W2046392024 cites W2074488860 @default.
- W2046392024 cites W2076051875 @default.
- W2046392024 cites W2078788771 @default.
- W2046392024 cites W2080632965 @default.
- W2046392024 cites W2082013520 @default.
- W2046392024 cites W2082699503 @default.
- W2046392024 cites W2087143040 @default.
- W2046392024 cites W2087396971 @default.
- W2046392024 cites W2089178801 @default.
- W2046392024 cites W2090315031 @default.
- W2046392024 cites W2094616210 @default.
- W2046392024 cites W2097241494 @default.
- W2046392024 cites W2098412291 @default.
- W2046392024 cites W2104611038 @default.
- W2046392024 cites W2115070641 @default.
- W2046392024 cites W2122973173 @default.
- W2046392024 cites W2128964866 @default.
- W2046392024 cites W2129357751 @default.
- W2046392024 cites W2134977136 @default.
- W2046392024 cites W2139220014 @default.
- W2046392024 cites W2139378518 @default.
- W2046392024 cites W2141158257 @default.
- W2046392024 cites W2146284752 @default.
- W2046392024 cites W2146653873 @default.
- W2046392024 cites W2148919158 @default.
- W2046392024 cites W2150689492 @default.
- W2046392024 cites W2156206992 @default.
- W2046392024 cites W2157557422 @default.
- W2046392024 cites W2159633856 @default.
- W2046392024 cites W2160222704 @default.
- W2046392024 cites W2161165271 @default.
- W2046392024 cites W2171495397 @default.