FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046392396> ?p ?o ?g. }

• W2046392396 endingPage "6947" @default.
• W2046392396 startingPage "6936" @default.
• W2046392396 abstract "Histone deacetylases (HDACs) play an important role in gene transcription. Inhibitors of HDACs induce cell differentiation and suppress cell proliferation in tumor cells. Although many HDAC inhibitors have been designed and synthesized, selective inhibition for class I HDAC isoforms is a goal that has yet to be achieved. To understand the difference between class I HDAC isoforms that could be exploited for the design of isoform-specific HDAC inhibitors, we have built three-dimensional models of four class I histone deacetylases, HDAC1, HDAC2, HDAC3, and HDAC8. Comparison of the homology model of HDAC8 with the recently published X-ray structure shows excellent agreement and validates the approach. A series of HDAC inhibitors were docked to the homology models to understand the similarities and differences between the binding modes. Molecular dynamic simulations of these HDAC−inhibitor complexes indicate that the interaction between the protein surface and inhibitor is playing an important role; also some active site residues show some flexibility, which is usually not included in routine docking protocols. The implications of these results for the design of isoform-selective HDAC inhibitors are discussed." @default.
• W2046392396 created "2016-06-24" @default.
• W2046392396 creator A5006603399 @default.
• W2046392396 creator A5018955027 @default.
• W2046392396 creator A5025245078 @default.
• W2046392396 creator A5029114040 @default.
• W2046392396 date "2005-10-12" @default.
• W2046392396 modified "2023-10-11" @default.
• W2046392396 title "Toward Selective Histone Deacetylase Inhibitor Design: Homology Modeling, Docking Studies, and Molecular Dynamics Simulations of Human Class I Histone Deacetylases" @default.
• W2046392396 cites W1635667563 @default.
• W2046392396 cites W1665024321 @default.
• W2046392396 cites W1976161355 @default.
• W2046392396 cites W1976499671 @default.
• W2046392396 cites W1981207136 @default.
• W2046392396 cites W1982619775 @default.
• W2046392396 cites W1998904806 @default.
• W2046392396 cites W2000219496 @default.
• W2046392396 cites W2008340135 @default.
• W2046392396 cites W2020293499 @default.
• W2046392396 cites W2023404623 @default.
• W2046392396 cites W2026649417 @default.
• W2046392396 cites W2032328453 @default.
• W2046392396 cites W2051152566 @default.
• W2046392396 cites W2055337326 @default.
• W2046392396 cites W2065283382 @default.
• W2046392396 cites W2071072200 @default.
• W2046392396 cites W2106882534 @default.
• W2046392396 cites W2112351720 @default.
• W2046392396 cites W2121296685 @default.
• W2046392396 cites W2134009718 @default.
• W2046392396 cites W2135830745 @default.
• W2046392396 cites W2158534713 @default.
• W2046392396 cites W2165011009 @default.
• W2046392396 cites W4255691026 @default.
• W2046392396 doi "https://doi.org/10.1021/jm0505011" @default.
• W2046392396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16250652" @default.
• W2046392396 hasPublicationYear "2005" @default.
• W2046392396 type Work @default.
• W2046392396 sameAs 2046392396 @default.
• W2046392396 citedByCount "192" @default.
• W2046392396 countsByYear W20463923962012 @default.
• W2046392396 countsByYear W20463923962013 @default.
• W2046392396 countsByYear W20463923962014 @default.
• W2046392396 countsByYear W20463923962015 @default.
• W2046392396 countsByYear W20463923962016 @default.
• W2046392396 countsByYear W20463923962017 @default.
• W2046392396 countsByYear W20463923962018 @default.
• W2046392396 countsByYear W20463923962019 @default.
• W2046392396 countsByYear W20463923962020 @default.
• W2046392396 countsByYear W20463923962021 @default.
• W2046392396 countsByYear W20463923962022 @default.
• W2046392396 countsByYear W20463923962023 @default.
• W2046392396 crossrefType "journal-article" @default.
• W2046392396 hasAuthorship W2046392396A5006603399 @default.
• W2046392396 hasAuthorship W2046392396A5018955027 @default.
• W2046392396 hasAuthorship W2046392396A5025245078 @default.
• W2046392396 hasAuthorship W2046392396A5029114040 @default.
• W2046392396 hasConcept C104317684 @default.
• W2046392396 hasConcept C13721689 @default.
• W2046392396 hasConcept C159110408 @default.
• W2046392396 hasConcept C169627665 @default.
• W2046392396 hasConcept C181199279 @default.
• W2046392396 hasConcept C185592680 @default.
• W2046392396 hasConcept C25737173 @default.
• W2046392396 hasConcept C27253355 @default.
• W2046392396 hasConcept C2778305200 @default.
• W2046392396 hasConcept C41685203 @default.
• W2046392396 hasConcept C4951695 @default.
• W2046392396 hasConcept C53345823 @default.
• W2046392396 hasConcept C55493867 @default.
• W2046392396 hasConcept C58793620 @default.
• W2046392396 hasConcept C64927066 @default.
• W2046392396 hasConcept C70721500 @default.
• W2046392396 hasConcept C71723506 @default.
• W2046392396 hasConcept C71924100 @default.
• W2046392396 hasConcept C85240754 @default.
• W2046392396 hasConcept C86803240 @default.
• W2046392396 hasConcept C95444343 @default.
• W2046392396 hasConceptScore W2046392396C104317684 @default.
• W2046392396 hasConceptScore W2046392396C13721689 @default.
• W2046392396 hasConceptScore W2046392396C159110408 @default.
• W2046392396 hasConceptScore W2046392396C169627665 @default.
• W2046392396 hasConceptScore W2046392396C181199279 @default.
• W2046392396 hasConceptScore W2046392396C185592680 @default.
• W2046392396 hasConceptScore W2046392396C25737173 @default.
• W2046392396 hasConceptScore W2046392396C27253355 @default.
• W2046392396 hasConceptScore W2046392396C2778305200 @default.
• W2046392396 hasConceptScore W2046392396C41685203 @default.
• W2046392396 hasConceptScore W2046392396C4951695 @default.
• W2046392396 hasConceptScore W2046392396C53345823 @default.
• W2046392396 hasConceptScore W2046392396C55493867 @default.
• W2046392396 hasConceptScore W2046392396C58793620 @default.
• W2046392396 hasConceptScore W2046392396C64927066 @default.
• W2046392396 hasConceptScore W2046392396C70721500 @default.
• W2046392396 hasConceptScore W2046392396C71723506 @default.
• W2046392396 hasConceptScore W2046392396C71924100 @default.
• W2046392396 hasConceptScore W2046392396C85240754 @default.
• W2046392396 hasConceptScore W2046392396C86803240 @default.

• next