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• W2046393119 abstract "Objectives Cervicofacial lymphadenitis is the most common manifestation of infection with non-tuberculous mycobacteria (NTM) in immunocompetent children. Although complete excision is considered standard management, the optimal treatment remains controversial. This study reviews the evidence for different management options for NTM lymphadenitis. Methods A systematic literature review and meta-analysis were performed including 1951 children from sixty publications. Generalised linear mixed model regressions were used to compare treatment modalities. Results The adjusted mean cure rate was 98% (95% CI 97.0–99.5%) for complete excision, 73.1% (95% CI 49.6–88.3%) for anti-mycobacterial antibiotics, and 70.4% (95% CI 49.6–88.3%) for ‘no intervention’. Compared to ‘no intervention’, only complete excision was significantly associated with cure (OR 33.1; 95% CI 10.8–102.9; p < 0.001). Complete excision was associated with a 10% risk of facial nerve palsy (2% permanent). ‘No intervention’ was associated with delayed resolution. Conclusions Complete excision is associated with the highest cure rate in NTM cervicofacial lymphadenitis, but also had the highest risk of facial nerve palsy. In the absence of large, well-designed RCTs, the choice between surgical excision, anti-mycobacterial antibiotics and ‘no intervention’ should be based on the location and extent of the disease, and acceptability of prolonged time to resolution." @default.
• W2046393119 created "2016-06-24" @default.
• W2046393119 creator A5016860965 @default.
• W2046393119 creator A5047137005 @default.
• W2046393119 creator A5067299658 @default.
• W2046393119 creator A5079507328 @default.
• W2046393119 date "2015-07-01" @default.
• W2046393119 modified "2023-10-16" @default.
• W2046393119 title "The management of non-tuberculous cervicofacial lymphadenitis in children: A systematic review and meta-analysis" @default.
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• W2046393119 doi "https://doi.org/10.1016/j.jinf.2015.02.010" @default.
• W2046393119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25727993" @default.
• W2046393119 hasPublicationYear "2015" @default.
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