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• W2046394098 abstract "<b><i>Objectives:</i></b> Several assays for the measurement of cardiac troponin (cTn) are available, but differences in their analytical performances may affect the diagnosis of acute myocardial infarction (MI). <b><i>Methods:</i></b> A survey was conducted at all Danish departments of clinical biochemistry at hospitals receiving patients with suspected acute MI to gather information about the assay and cut-off value used. cTn was measured in blood samples from 574 patients enrolled into the Odense Chest Pain Biobank with 3 different assays: the 4th generation cTnT (cTnT^4th), high-sensitivity cTnT (cTnT^hs; Roche Diagnostics) and cTnI (Abbott Diagnostics). To evaluate concordance, patients were dichotomised according to the 99th percentile value for each assay. Additionally, a cut-off at 50 ng/l for cTnT^hs was used, as this is the currently employed cut-off point in Denmark. <b><i>Results:</i></b> Using a cTnT^4th cut-off value of >0.03 µg/l, 130 patients (23%) had potential MI. With the cTnT^hs assay and cut-off values at 50 versus 14 ng/l, respectively, 136 (24%) versus 301 (52%) patients had potential MI. With the cTnI cut-off point, 205 patients (36%) should be considered as having had an acute MI. <b><i>Conclusions:</i></b> The use of different cTn assays and cut-off values may result in a discordant frequency of MI diagnoses. This makes efforts to harmonize cTn assays and cut-off levels mandatory." @default.
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• W2046394098 date "2012-01-01" @default.
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• W2046394098 title "Discordant Diagnoses of Acute Myocardial Infarction due to the Different Use of Assays and Cut-Off Points of Cardiac Troponins" @default.
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• W2046394098 doi "https://doi.org/10.1159/000339269" @default.
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