Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046394564> ?p ?o ?g. }
- W2046394564 endingPage "360" @default.
- W2046394564 startingPage "351" @default.
- W2046394564 abstract "We have investigated the function of the retinoic acid metabolising enzyme, CYP26B1, by administering an antisense morpholino oligonucleotide to zebrafish embryos. The result was an alteration in the morphology of the embryo in those regions which express the gene, namely an embryo with a smaller head, correspondingly smaller hindbrain rhombomeres and severely reduced numbers of vagal brachiomotor neurons. Most strikingly, these embryos had defective or absent jaw cartilages implying a role for this enzyme in patterning or migration of the neural crest cells which give rise to this tissue type. In order to determine whether this phenotype resembles that of excess retinoic acid or a deficiency of retinoic acid, we compared the jaw defects following retinoic acid treatment or DEAB treatment, the latter being an inhibitor of retinoic acid synthesis. The effects of the inhibitor rather than excess retinoic acid most closely phenocopied the jaw defects seen with the <I>Cyp26B1</I> morpholino which suggests that, at least in the zebrafish embryo, the action of CYP26B1 in the neural crest may not be simply to catabolise all-<I>trans</I>-RA." @default.
- W2046394564 created "2016-06-24" @default.
- W2046394564 creator A5018907985 @default.
- W2046394564 creator A5025229965 @default.
- W2046394564 creator A5046588380 @default.
- W2046394564 date "2007-01-01" @default.
- W2046394564 modified "2023-10-17" @default.
- W2046394564 title "The retinoic acid metabolising gene, CYP26B1, patterns the cartilaginous cranial neural crest in zebrafish" @default.
- W2046394564 cites W128790911 @default.
- W2046394564 cites W1547869018 @default.
- W2046394564 cites W1556198965 @default.
- W2046394564 cites W1939881246 @default.
- W2046394564 cites W1965085886 @default.
- W2046394564 cites W1965890116 @default.
- W2046394564 cites W1967165814 @default.
- W2046394564 cites W1968916721 @default.
- W2046394564 cites W1973021296 @default.
- W2046394564 cites W1976261033 @default.
- W2046394564 cites W1978628739 @default.
- W2046394564 cites W1978973930 @default.
- W2046394564 cites W1980397209 @default.
- W2046394564 cites W1987958985 @default.
- W2046394564 cites W1988917710 @default.
- W2046394564 cites W1998681781 @default.
- W2046394564 cites W2000858150 @default.
- W2046394564 cites W2001228043 @default.
- W2046394564 cites W2001642371 @default.
- W2046394564 cites W2003697552 @default.
- W2046394564 cites W2006877541 @default.
- W2046394564 cites W2013126973 @default.
- W2046394564 cites W2016392505 @default.
- W2046394564 cites W2017087879 @default.
- W2046394564 cites W2019899002 @default.
- W2046394564 cites W2023895471 @default.
- W2046394564 cites W2027876857 @default.
- W2046394564 cites W2028791419 @default.
- W2046394564 cites W2033154232 @default.
- W2046394564 cites W2055088146 @default.
- W2046394564 cites W2058792174 @default.
- W2046394564 cites W2062278718 @default.
- W2046394564 cites W2062953025 @default.
- W2046394564 cites W2064285041 @default.
- W2046394564 cites W2067013525 @default.
- W2046394564 cites W2074038170 @default.
- W2046394564 cites W2084050360 @default.
- W2046394564 cites W2085511966 @default.
- W2046394564 cites W2092604039 @default.
- W2046394564 cites W2099841716 @default.
- W2046394564 cites W2103523795 @default.
- W2046394564 cites W2115833116 @default.
- W2046394564 cites W2117939818 @default.
- W2046394564 cites W2122146446 @default.
- W2046394564 cites W2156684099 @default.
- W2046394564 cites W2162113441 @default.
- W2046394564 cites W2165108884 @default.
- W2046394564 cites W2166256370 @default.
- W2046394564 cites W2169920445 @default.
- W2046394564 cites W2276715922 @default.
- W2046394564 cites W2278234077 @default.
- W2046394564 cites W2337661590 @default.
- W2046394564 cites W2404177877 @default.
- W2046394564 cites W2410634194 @default.
- W2046394564 cites W2413861371 @default.
- W2046394564 doi "https://doi.org/10.1387/ijdb.062258sr" @default.
- W2046394564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17616924" @default.
- W2046394564 hasPublicationYear "2007" @default.
- W2046394564 type Work @default.
- W2046394564 sameAs 2046394564 @default.
- W2046394564 citedByCount "29" @default.
- W2046394564 countsByYear W20463945642012 @default.
- W2046394564 countsByYear W20463945642013 @default.
- W2046394564 countsByYear W20463945642014 @default.
- W2046394564 countsByYear W20463945642016 @default.
- W2046394564 countsByYear W20463945642017 @default.
- W2046394564 countsByYear W20463945642019 @default.
- W2046394564 countsByYear W20463945642020 @default.
- W2046394564 countsByYear W20463945642021 @default.
- W2046394564 countsByYear W20463945642022 @default.
- W2046394564 crossrefType "journal-article" @default.
- W2046394564 hasAuthorship W2046394564A5018907985 @default.
- W2046394564 hasAuthorship W2046394564A5025229965 @default.
- W2046394564 hasAuthorship W2046394564A5046588380 @default.
- W2046394564 hasBestOaLocation W20463945641 @default.
- W2046394564 hasConcept C104317684 @default.
- W2046394564 hasConcept C111039654 @default.
- W2046394564 hasConcept C126749454 @default.
- W2046394564 hasConcept C136571751 @default.
- W2046394564 hasConcept C150194340 @default.
- W2046394564 hasConcept C18903297 @default.
- W2046394564 hasConcept C196843134 @default.
- W2046394564 hasConcept C2776878037 @default.
- W2046394564 hasConcept C2777075493 @default.
- W2046394564 hasConcept C2777948982 @default.
- W2046394564 hasConcept C2780071072 @default.
- W2046394564 hasConcept C2780594696 @default.
- W2046394564 hasConcept C2781121885 @default.
- W2046394564 hasConcept C2781465898 @default.
- W2046394564 hasConcept C55493867 @default.