FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046395230> ?p ?o ?g. }

• W2046395230 abstract "1. The effect of the selective histamine H3 receptor agonist, R-alpha-methylhistamine given intravenously (10-100 micrograms kg-1) was examined on baseline total peripheral resistance (TPR), and cardiovascular haemodynamics in bilaterally vagotomized, anaesthetized guinea-pigs. 2. R-alpha-methylhistamine produced a dose-dependent hypotension and fall in TPR at 30 and 100 micrograms kg-1. A decrease in heart rate (HR) was observed at a dose of 100 micrograms kg-1. R-alpha-methylhistamine (10-100 micrograms kg-1) also produced a dose-dependent fall in rate pressure product (RPP). There was no effect on cardiac output (CO) or stroke volume (SV) at these doses. 3. Histamine H1 and H2 blockade in animals pretreated with a combination of chlorpheniramine (0.3 mg kg-1) and cimetidine (3.0 mg kg-1) did not alter the haemodynamic actions of R-alpha-methyl-histamine (100 micrograms kg-1, i.v.). Pretreatment with the selective H3 antagonist, thioperamide (1 mg kg-1), completely blocked the action of R-alpha-methylhistamine on haemodynamic parameters. 4. To study the mechanism of action of R-alpha-methylhistamine, the vasodilator hydralazine (1 mg kg-1, i.v.) was used. Hydralazine lowered BP, TRP and RPP in guinea-pigs pretreated with ipratropium (50 micrograms kg-1, i.v.). Hydralazine had no effect on HR, SV or CO. 5. R-alpha-methylhistamine (100 micrograms kg-1) did not affect the vasopressor action and increases in TPR produced by adrenaline (1 and 3 micrograms kg-1). On the other hand, the vasodilator hydralazine (1 mg kg-1, i.v.) inhibited the effects of adrenaline (3 micrograms kg-1) on TPR and RPP. The effect of both doses of adrenaline on BP were attenuated by hydralazine. Therefore, the inhibitory effects of R-alpha-methylhistamine are not mediated through a direct action on vascular smooth muscle.6. In adrenalectomized guinea-pigs, R-alpha-methylhistamine (100 microg kg-1) produced a drop in BP and HR.There was no difference between the effects of R-alpha-methylhistamine on blood pressure and heart rate in adrenalectomized and non-adrenalectomized guinea-pigs.7. These results show that activation of peripheral H3 receptors lowers basal BP, HR and TPR, most likely by a peripheral prejunctional mechanism. The fall in BP and TPR is probably due to a decrease in noradrenaline release from sympathetic effector nerves innervating the resistance blood vessels." @default.
• W2046395230 created "2016-06-24" @default.
• W2046395230 creator A5005005325 @default.
• W2046395230 creator A5052726523 @default.
• W2046395230 creator A5056003857 @default.
• W2046395230 date "1993-10-01" @default.
• W2046395230 modified "2023-10-18" @default.
• W2046395230 title "Production by R-α-methylhistamine of a histamine H3 receptor-mediated decrease in basal vascular resistance in guinea-pigs" @default.
• W2046395230 cites W1816755143 @default.
• W2046395230 cites W1894676325 @default.
• W2046395230 cites W1965235459 @default.
• W2046395230 cites W1982358202 @default.
• W2046395230 cites W1982996105 @default.
• W2046395230 cites W1996186003 @default.
• W2046395230 cites W1998488929 @default.
• W2046395230 cites W1999965805 @default.
• W2046395230 cites W2001079294 @default.
• W2046395230 cites W2007259021 @default.
• W2046395230 cites W2016528422 @default.
• W2046395230 cites W2030245775 @default.
• W2046395230 cites W2034697832 @default.
• W2046395230 cites W2039031830 @default.
• W2046395230 cites W2039191416 @default.
• W2046395230 cites W2049008173 @default.
• W2046395230 cites W2051579732 @default.
• W2046395230 cites W2055670234 @default.
• W2046395230 cites W2057973620 @default.
• W2046395230 cites W2064862410 @default.
• W2046395230 cites W2068640644 @default.
• W2046395230 cites W2077687762 @default.
• W2046395230 cites W2088756127 @default.
• W2046395230 cites W2126779491 @default.
• W2046395230 cites W2214169347 @default.
• W2046395230 cites W2240840041 @default.
• W2046395230 cites W2268003460 @default.
• W2046395230 cites W2965805822 @default.
• W2046395230 cites W4324125101 @default.
• W2046395230 doi "https://doi.org/10.1111/j.1476-5381.1993.tb13846.x" @default.
• W2046395230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2175947" @default.
• W2046395230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7902173" @default.
• W2046395230 hasPublicationYear "1993" @default.
• W2046395230 type Work @default.
• W2046395230 sameAs 2046395230 @default.
• W2046395230 citedByCount "25" @default.
• W2046395230 countsByYear W20463952302013 @default.
• W2046395230 countsByYear W20463952302018 @default.
• W2046395230 countsByYear W20463952302021 @default.
• W2046395230 crossrefType "journal-article" @default.
• W2046395230 hasAuthorship W2046395230A5005005325 @default.
• W2046395230 hasAuthorship W2046395230A5052726523 @default.
• W2046395230 hasAuthorship W2046395230A5056003857 @default.
• W2046395230 hasBestOaLocation W20463952302 @default.
• W2046395230 hasConcept C1122143 @default.
• W2046395230 hasConcept C120770815 @default.
• W2046395230 hasConcept C126322002 @default.
• W2046395230 hasConcept C134018914 @default.
• W2046395230 hasConcept C170493617 @default.
• W2046395230 hasConcept C185592680 @default.
• W2046395230 hasConcept C2778938600 @default.
• W2046395230 hasConcept C2778997900 @default.
• W2046395230 hasConcept C2780521442 @default.
• W2046395230 hasConcept C63180777 @default.
• W2046395230 hasConcept C71924100 @default.
• W2046395230 hasConcept C84393581 @default.
• W2046395230 hasConcept C98274493 @default.
• W2046395230 hasConceptScore W2046395230C1122143 @default.
• W2046395230 hasConceptScore W2046395230C120770815 @default.
• W2046395230 hasConceptScore W2046395230C126322002 @default.
• W2046395230 hasConceptScore W2046395230C134018914 @default.
• W2046395230 hasConceptScore W2046395230C170493617 @default.
• W2046395230 hasConceptScore W2046395230C185592680 @default.
• W2046395230 hasConceptScore W2046395230C2778938600 @default.
• W2046395230 hasConceptScore W2046395230C2778997900 @default.
• W2046395230 hasConceptScore W2046395230C2780521442 @default.
• W2046395230 hasConceptScore W2046395230C63180777 @default.
• W2046395230 hasConceptScore W2046395230C71924100 @default.
• W2046395230 hasConceptScore W2046395230C84393581 @default.
• W2046395230 hasConceptScore W2046395230C98274493 @default.
• W2046395230 hasLocation W20463952301 @default.
• W2046395230 hasLocation W20463952302 @default.
• W2046395230 hasLocation W20463952303 @default.
• W2046395230 hasLocation W20463952304 @default.
• W2046395230 hasOpenAccess W2046395230 @default.
• W2046395230 hasPrimaryLocation W20463952301 @default.
• W2046395230 hasRelatedWork W1964737882 @default.
• W2046395230 hasRelatedWork W1965692775 @default.
• W2046395230 hasRelatedWork W1981262775 @default.
• W2046395230 hasRelatedWork W1983315707 @default.
• W2046395230 hasRelatedWork W2015308087 @default.
• W2046395230 hasRelatedWork W2045265121 @default.
• W2046395230 hasRelatedWork W2172131010 @default.
• W2046395230 hasRelatedWork W2404186823 @default.
• W2046395230 hasRelatedWork W2413416188 @default.
• W2046395230 hasRelatedWork W910327846 @default.
• W2046395230 isParatext "false" @default.
• W2046395230 isRetracted "false" @default.
• W2046395230 magId "2046395230" @default.
• W2046395230 workType "article" @default.