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• W2046396329 endingPage "1650" @default.
• W2046396329 startingPage "1632" @default.
• W2046396329 abstract "Cyclic nitroxides are a diverse group range of stable free radicals that have unique antioxidant properties. Because of their ability to interact with free radicals, they have been used for many years as biophysical tools. During the past 15-20 years, however, many interesting biochemical interactions have been discovered and harnessed for therapeutic applications. Biologically relevant effects of nitroxides have been described, including their ability to degrade superoxide and peroxide, inhibit Fenton reactions, and undergo radical-radical recombination. Cellular studies defined the activity of nitroxides in vitro. By modifying oxidative stress and altering the redox status of tissues, nitroxides have been found to interact with and alter many metabolic processes. These interactions can be exploited for therapeutic and research use, including protection against ionizing radiation, as probes in functional magnetic resonance imaging, cancer prevention and treatment, control of hypertension and weight, and protection from damage resulting from ischemia/reperfusion injury. Although much remains to be done, many applications have been well studied and some are currently being tested in clinical trials. The therapeutic and research uses of nitroxide compounds are reviewed here with a focus on the progress from initial development to modern trials." @default.
• W2046396329 created "2016-06-24" @default.
• W2046396329 creator A5046742103 @default.
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• W2046396329 creator A5072939048 @default.
• W2046396329 creator A5081250782 @default.
• W2046396329 creator A5085728678 @default.
• W2046396329 date "2007-06-01" @default.
• W2046396329 modified "2023-10-03" @default.
• W2046396329 title "The chemistry and biology of nitroxide compounds" @default.
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