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• W2046396389 abstract "The autoinducer (AI) that initiates the quorum sensing (QS) signaling cascade in Pseudomonas aeruginosa is an acyl-homoserine lactone (acyl-HSL). We initiated a study of the requirements for binding of the AI to its protein effector LasR by synthesizing a library of analogs with the HSL moiety replaced with different amines and alcohols. We tested each compound for both agonist and antagonist activity using a QS-controlled reporter gene assay and found several new agonists and antagonists. A representative antagonist was further tested for its ability to inhibit virulence factors. This data progresses our understanding of the LasR-AI interaction toward the rational design of therapeutic inhibitors of QS." @default.
• W2046396389 created "2016-06-24" @default.
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• W2046396389 date "2003-06-01" @default.
• W2046396389 modified "2023-10-18" @default.
• W2046396389 title "Library Screening for Synthetic Agonists and Antagonists of a Pseudomonas aeruginosa Autoinducer" @default.
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• W2046396389 doi "https://doi.org/10.1016/s1074-5521(03)00107-8" @default.
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