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- W2046402005 abstract "The haemolytic activity encoded by thirteen hly-plasmids of different origin and sources was examined as a function of the Fe3+-concentration in E. coli fur+ and E. coli fur− strains, respectively. In E. coli fur+ the relatively low haemolytic activity of five hly-plasmids isolated in Berne and one isolated in Paris was increased significantly under iron-limiting growth conditions. Contrastingly, in E. coli fur− strains containing the same plasmids, a considerably higher amount of secreted haemolysin was detected. This activity could not be further increased by limiting the extracellular iron concentration. Seven other hly-plasmids expressed similar and non-inducible amounts of secreted haemolysin in both E. coli fur+ and E. coli fur− strains. These results indicate that the extracellular haemolytic activity encoded by certain hly-plasmids was controlled by the chromosomally encoded fur gene. Die Hämolyseaktivität von 13 Hly-Plasmiden unterschiedlicher Herkunft wurde in Abhängigkeit zur extrazellulären Eisenkonzentration in E. coli mit aktivem und inaktivem fur Gen untersucht. In E. coli fur+ wurde die relativ geringe Hämolyseaktivität der 5 Hly-Plasmide aus Bern und eines Hly-Plasmids aus Paris bei Limitierung des extrazellulären Eisens signifikant erhöht. Dagegen war in E. coli fur− bei den selben Plasmiden die Hämolyseaktivität deutlich höher, wurde jedoch bei Eisenlimitierung nicht weiter erhöht. Die 7 anderen Hly-Plasmide kodierten sowohl in E. coli fur+ als auch in E. coli fur− eine hohe, nicht induzierbare Hämolysinsekretion. Die Ergebnisse zeigen, daß die Hämolyseaktivität bestimmter Hly-Plasmide durch das chromosomal kodierte fur Gen reguliert wird." @default.
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- W2046402005 date "1987-08-01" @default.
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- W2046402005 title "The chromosomal fur gene regulates the extracellular haemolytic activiy encoded by certain hly plasmids" @default.
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- W2046402005 doi "https://doi.org/10.1016/s0176-6724(87)80036-6" @default.
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