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- W2046403032 abstract "Mechanically generated radicals were shown to affect short-term stability of a model pharmaceutical formulation during high-shear processing. A formulation containing an oxidatively sensitive drug, either amorphous or crystalline, and a polymeric excipient was high-shear mixed and the resulting short-term degradation was determined with HPLC. High-shear mixing of the excipients was also carried out before drug addition to isolate effects on excipients versus those directly on the drug. Short-term drug stability was found to be strongly dependent on the amount of shear added to excipients prior to drug addition, regardless of morphology. A mechanism for the observed degradation based on mechanically generated radicals from microcrystalline cellulose is proposed. These results indicate that excipient high-shear exposure needs to be considered in regards to drug stability." @default.
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- W2046403032 date "2008-01-01" @default.
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- W2046403032 title "Mechanoradical-Induced Degradation in a Pharmaceutical Blend during High-Shear Processing" @default.
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- W2046403032 doi "https://doi.org/10.1080/10837450802328869" @default.
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