Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046408066> ?p ?o ?g. }
- W2046408066 endingPage "42" @default.
- W2046408066 startingPage "34" @default.
- W2046408066 abstract "Metformin is a commonly used anti-diabetic drug with AMP-activated protein kinase (AMPK)-dependent hypoglycemic activities. Recent studies have revealed its anti-inflammatory and anti-oxidative properties. In the present study, the anti-oxidative potential of metformin and its potential mechanisms were investigated in a mouse model with carbon tetrachloride (CCl4)-induced severe oxidative liver injury. Our results showed that treatment with metformin significantly attenuated CCl4-induced elevation of serum aminotransferases and hepatic histological abnormalities. The alleviated liver injury was associated with decreased hepatic contents of oxidized glutathione (GSSG) and malondialdehyde (MDA). In addition, metformin treatment dose-dependently enhanced the activities of catalase (CAT) and decreased CCl4-induced elevation of hepatic H2O2 levels, but it had no obvious effects on the protein level of CAT. We also found that metformin increased the level of phosphorylated AMP-activated protein kinase (AMPK), but treatment with AMPK activator AICAR had no obvious effects on CAT activity. A molecular docking analysis indicated that metformin might interact with CAT via hydrogen bonds. These data suggested that metformin effectively alleviated CCl4-induced oxidative liver injury in mice and these hepatoprotective effects might be associated with CAT." @default.
- W2046408066 created "2016-06-24" @default.
- W2046408066 creator A5001961997 @default.
- W2046408066 creator A5014681852 @default.
- W2046408066 creator A5025545331 @default.
- W2046408066 creator A5042807284 @default.
- W2046408066 creator A5052591988 @default.
- W2046408066 creator A5057978927 @default.
- W2046408066 creator A5066716873 @default.
- W2046408066 creator A5074942308 @default.
- W2046408066 creator A5082599349 @default.
- W2046408066 creator A5087522454 @default.
- W2046408066 date "2014-06-01" @default.
- W2046408066 modified "2023-10-17" @default.
- W2046408066 title "Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury" @default.
- W2046408066 cites W172727457 @default.
- W2046408066 cites W1966558949 @default.
- W2046408066 cites W1972009654 @default.
- W2046408066 cites W1974773445 @default.
- W2046408066 cites W1979161827 @default.
- W2046408066 cites W1983708132 @default.
- W2046408066 cites W1987224043 @default.
- W2046408066 cites W1989555949 @default.
- W2046408066 cites W2000499892 @default.
- W2046408066 cites W2003849566 @default.
- W2046408066 cites W2010094057 @default.
- W2046408066 cites W2012022623 @default.
- W2046408066 cites W2020681473 @default.
- W2046408066 cites W2021143006 @default.
- W2046408066 cites W2025130292 @default.
- W2046408066 cites W2026231752 @default.
- W2046408066 cites W2054888659 @default.
- W2046408066 cites W2055059005 @default.
- W2046408066 cites W2056608735 @default.
- W2046408066 cites W2059642778 @default.
- W2046408066 cites W2062991061 @default.
- W2046408066 cites W2071633757 @default.
- W2046408066 cites W2075549059 @default.
- W2046408066 cites W2086416610 @default.
- W2046408066 cites W2091754536 @default.
- W2046408066 cites W2092340120 @default.
- W2046408066 cites W2094375546 @default.
- W2046408066 cites W2094489662 @default.
- W2046408066 cites W2097460049 @default.
- W2046408066 cites W2101332185 @default.
- W2046408066 cites W2105731956 @default.
- W2046408066 cites W2111370380 @default.
- W2046408066 cites W2116342732 @default.
- W2046408066 cites W2117069393 @default.
- W2046408066 cites W2120671198 @default.
- W2046408066 cites W2121386098 @default.
- W2046408066 cites W2123729941 @default.
- W2046408066 cites W2126753352 @default.
- W2046408066 cites W2138226825 @default.
- W2046408066 cites W2140603619 @default.
- W2046408066 cites W2147993424 @default.
- W2046408066 cites W2171294019 @default.
- W2046408066 cites W4245367233 @default.
- W2046408066 doi "https://doi.org/10.1016/j.cbi.2014.03.013" @default.
- W2046408066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24717679" @default.
- W2046408066 hasPublicationYear "2014" @default.
- W2046408066 type Work @default.
- W2046408066 sameAs 2046408066 @default.
- W2046408066 citedByCount "43" @default.
- W2046408066 countsByYear W20464080662015 @default.
- W2046408066 countsByYear W20464080662016 @default.
- W2046408066 countsByYear W20464080662017 @default.
- W2046408066 countsByYear W20464080662018 @default.
- W2046408066 countsByYear W20464080662019 @default.
- W2046408066 countsByYear W20464080662020 @default.
- W2046408066 countsByYear W20464080662021 @default.
- W2046408066 countsByYear W20464080662022 @default.
- W2046408066 countsByYear W20464080662023 @default.
- W2046408066 crossrefType "journal-article" @default.
- W2046408066 hasAuthorship W2046408066A5001961997 @default.
- W2046408066 hasAuthorship W2046408066A5014681852 @default.
- W2046408066 hasAuthorship W2046408066A5025545331 @default.
- W2046408066 hasAuthorship W2046408066A5042807284 @default.
- W2046408066 hasAuthorship W2046408066A5052591988 @default.
- W2046408066 hasAuthorship W2046408066A5057978927 @default.
- W2046408066 hasAuthorship W2046408066A5066716873 @default.
- W2046408066 hasAuthorship W2046408066A5074942308 @default.
- W2046408066 hasAuthorship W2046408066A5082599349 @default.
- W2046408066 hasAuthorship W2046408066A5087522454 @default.
- W2046408066 hasConcept C102124568 @default.
- W2046408066 hasConcept C126322002 @default.
- W2046408066 hasConcept C134018914 @default.
- W2046408066 hasConcept C178790620 @default.
- W2046408066 hasConcept C181199279 @default.
- W2046408066 hasConcept C184235292 @default.
- W2046408066 hasConcept C185592680 @default.
- W2046408066 hasConcept C2776151105 @default.
- W2046408066 hasConcept C2776637226 @default.
- W2046408066 hasConcept C2776780712 @default.
- W2046408066 hasConcept C2777359374 @default.
- W2046408066 hasConcept C2778401633 @default.
- W2046408066 hasConcept C2778979269 @default.
- W2046408066 hasConcept C2780124434 @default.