FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046408068> ?p ?o ?g. }

• W2046408068 endingPage "63" @default.
• W2046408068 startingPage "57" @default.
• W2046408068 abstract "Central cholinergic (ACh) projections have been shown to modulate stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis and are integral to the expression of electrophysiological correlates of arousal, namely hippocampal theta rhythm. The degree to which these actions of ACh are behaviorally relevant has received comparatively less attention, and we sought to investigate if manipulations of ACh systems might also affect behaviors related to stress and arousal. We chose to examine indices of anxiety as revealed by changes in behavior elicited by the black-white box test, a relatively novel and recently validated model of rodent anxiety. Groups of rats were injected with either scopolamine hydrobromide (SCOP; 0, 0.05, and 0.10 mg/kg i.p.) or the peripherally acting scopolamine methyl bromide (methyl-SCOP; 0, 0.05, and 0.10 mg/kg i.p.) to compare and contrast the effects of central and peripheral ACh blockade on measures of anxiety. SCOP pretreatment significantly lowered latencies for rats to escape from the white to black compartment, while methyl-SCOP elevated latencies to reenter the white chamber from the black. Both drugs increased the amount of time rats spent in the black compartment and also suppressed exploration as revealed by decreased episodes of intercompartmental locomotion. Neither drug deleteriously affected locomotor activity, however; in fact, SCOP significantly increased locomotion in the white chamber. In the absence of motor disturbances to account for any group differences, we contend that both central and peripheral ACh blockade may affect measures of anxiety, perhaps by directly or indirectly affecting HPA activity. Central ACh systems may underlie sensory filtering whereby irrelevant stimuli are excluded from sensory processing. Antagonism of ACh transmission may render an animal incapable of correctly processing sensory information leading to hyperresponsiveness, which can manifest itself as enhanced anxiety and fear." @default.
• W2046408068 created "2016-06-24" @default.
• W2046408068 creator A5005933989 @default.
• W2046408068 creator A5005944709 @default.
• W2046408068 creator A5032175276 @default.
• W2046408068 creator A5060211915 @default.
• W2046408068 creator A5073512303 @default.
• W2046408068 date "1996-05-01" @default.
• W2046408068 modified "2023-09-24" @default.
• W2046408068 title "Muscarinic antagonists are anxiogenic in rats tested in the black-white box" @default.
• W2046408068 cites W1973372728 @default.
• W2046408068 cites W1983793840 @default.
• W2046408068 cites W1986199494 @default.
• W2046408068 cites W1988909397 @default.
• W2046408068 cites W1993109188 @default.
• W2046408068 cites W1995759274 @default.
• W2046408068 cites W1998532707 @default.
• W2046408068 cites W2002108194 @default.
• W2046408068 cites W2005078651 @default.
• W2046408068 cites W2019872918 @default.
• W2046408068 cites W2027009747 @default.
• W2046408068 cites W2027066860 @default.
• W2046408068 cites W2033476408 @default.
• W2046408068 cites W2036818530 @default.
• W2046408068 cites W2044436505 @default.
• W2046408068 cites W2052361796 @default.
• W2046408068 cites W2055067912 @default.
• W2046408068 cites W2059981865 @default.
• W2046408068 cites W2062706679 @default.
• W2046408068 cites W2063281437 @default.
• W2046408068 cites W2068863027 @default.
• W2046408068 cites W2070971788 @default.
• W2046408068 cites W2090424711 @default.
• W2046408068 cites W2110137652 @default.
• W2046408068 cites W2126809665 @default.
• W2046408068 cites W2151340091 @default.
• W2046408068 cites W2169284978 @default.
• W2046408068 cites W4238599819 @default.
• W2046408068 cites W4247789823 @default.
• W2046408068 doi "https://doi.org/10.1016/0091-3057(95)02130-2" @default.
• W2046408068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8728539" @default.
• W2046408068 hasPublicationYear "1996" @default.
• W2046408068 type Work @default.
• W2046408068 sameAs 2046408068 @default.
• W2046408068 citedByCount "85" @default.
• W2046408068 countsByYear W20464080682012 @default.
• W2046408068 countsByYear W20464080682013 @default.
• W2046408068 countsByYear W20464080682014 @default.
• W2046408068 countsByYear W20464080682015 @default.
• W2046408068 countsByYear W20464080682017 @default.
• W2046408068 countsByYear W20464080682018 @default.
• W2046408068 countsByYear W20464080682019 @default.
• W2046408068 countsByYear W20464080682021 @default.
• W2046408068 countsByYear W20464080682022 @default.
• W2046408068 countsByYear W20464080682023 @default.
• W2046408068 crossrefType "journal-article" @default.
• W2046408068 hasAuthorship W2046408068A5005933989 @default.
• W2046408068 hasAuthorship W2046408068A5005944709 @default.
• W2046408068 hasAuthorship W2046408068A5032175276 @default.
• W2046408068 hasAuthorship W2046408068A5060211915 @default.
• W2046408068 hasAuthorship W2046408068A5073512303 @default.
• W2046408068 hasConcept C118552586 @default.
• W2046408068 hasConcept C126322002 @default.
• W2046408068 hasConcept C134018914 @default.
• W2046408068 hasConcept C15744967 @default.
• W2046408068 hasConcept C169760540 @default.
• W2046408068 hasConcept C170493617 @default.
• W2046408068 hasConcept C173586616 @default.
• W2046408068 hasConcept C205044023 @default.
• W2046408068 hasConcept C22885893 @default.
• W2046408068 hasConcept C2775910092 @default.
• W2046408068 hasConcept C2777765862 @default.
• W2046408068 hasConcept C2778468042 @default.
• W2046408068 hasConcept C36951298 @default.
• W2046408068 hasConcept C558461103 @default.
• W2046408068 hasConcept C71924100 @default.
• W2046408068 hasConcept C98274493 @default.
• W2046408068 hasConceptScore W2046408068C118552586 @default.
• W2046408068 hasConceptScore W2046408068C126322002 @default.
• W2046408068 hasConceptScore W2046408068C134018914 @default.
• W2046408068 hasConceptScore W2046408068C15744967 @default.
• W2046408068 hasConceptScore W2046408068C169760540 @default.
• W2046408068 hasConceptScore W2046408068C170493617 @default.
• W2046408068 hasConceptScore W2046408068C173586616 @default.
• W2046408068 hasConceptScore W2046408068C205044023 @default.
• W2046408068 hasConceptScore W2046408068C22885893 @default.
• W2046408068 hasConceptScore W2046408068C2775910092 @default.
• W2046408068 hasConceptScore W2046408068C2777765862 @default.
• W2046408068 hasConceptScore W2046408068C2778468042 @default.
• W2046408068 hasConceptScore W2046408068C36951298 @default.
• W2046408068 hasConceptScore W2046408068C558461103 @default.
• W2046408068 hasConceptScore W2046408068C71924100 @default.
• W2046408068 hasConceptScore W2046408068C98274493 @default.
• W2046408068 hasIssue "1" @default.
• W2046408068 hasLocation W20464080681 @default.
• W2046408068 hasLocation W20464080682 @default.
• W2046408068 hasOpenAccess W2046408068 @default.
• W2046408068 hasPrimaryLocation W20464080681 @default.

• next