Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046408384> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2046408384 abstract "Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CAPharmacological targeting of metabolic processes in cancer must overcome redundancy in biosynthetic pathways. Deoxycytidine triphosphate (dCTP) can be produced by the de novo pathway (DNP) via ribonucleotide reductase, and/or by the nucleoside salvage pathway (NSP) via deoxycytidine kinase (dCK). The NSP's role in supporting tumor DNA replication is unknown. Here we show that survival of acute lymphoblastic leukemia cells upon inhibition of DNP-dependent dCTP production requires a functional NSP. Thus, DNP inhibition triggers a compensatory switch to NSP-mediated dCTP production. This metabolic switch can be imaged by positron emission tomography, thereby providing a non-invasive method for monitoring pharmacological targeting of the DNP. Blocking both DNP dCTP production using thymidine and the switch to NSP using a new dCK inhibitor induces replication stress overload and synthetic lethality in leukemia cells, without significant host toxicity. This co-targeting therapy may be broadly applicable against other malignancies characterized by high levels of replication stress.Citation Format: Caius G. Radu, David A. Nathanson, Johannes Czernin. Co-targeting of convergent, switchable nucleotide biosynthetic pathways induces synthetic lethality in leukemia. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5097. doi:10.1158/1538-7445.AM2014-5097" @default.
- W2046408384 created "2016-06-24" @default.
- W2046408384 creator A5004206249 @default.
- W2046408384 creator A5018755772 @default.
- W2046408384 creator A5035254202 @default.
- W2046408384 date "2014-09-30" @default.
- W2046408384 modified "2023-09-27" @default.
- W2046408384 title "Abstract 5097: Co-targeting of convergent, switchable nucleotide biosynthetic pathways induces synthetic lethality in leukemia" @default.
- W2046408384 doi "https://doi.org/10.1158/1538-7445.am2014-5097" @default.
- W2046408384 hasPublicationYear "2014" @default.
- W2046408384 type Work @default.
- W2046408384 sameAs 2046408384 @default.
- W2046408384 citedByCount "0" @default.
- W2046408384 crossrefType "proceedings-article" @default.
- W2046408384 hasAuthorship W2046408384A5004206249 @default.
- W2046408384 hasAuthorship W2046408384A5018755772 @default.
- W2046408384 hasAuthorship W2046408384A5035254202 @default.
- W2046408384 hasConcept C104292427 @default.
- W2046408384 hasConcept C104317684 @default.
- W2046408384 hasConcept C121608353 @default.
- W2046408384 hasConcept C134935766 @default.
- W2046408384 hasConcept C143425029 @default.
- W2046408384 hasConcept C184235292 @default.
- W2046408384 hasConcept C185592680 @default.
- W2046408384 hasConcept C194101687 @default.
- W2046408384 hasConcept C2777844706 @default.
- W2046408384 hasConcept C2778461978 @default.
- W2046408384 hasConcept C2778502085 @default.
- W2046408384 hasConcept C2779268695 @default.
- W2046408384 hasConcept C2780258809 @default.
- W2046408384 hasConcept C4710235 @default.
- W2046408384 hasConcept C502942594 @default.
- W2046408384 hasConcept C512185932 @default.
- W2046408384 hasConcept C54355233 @default.
- W2046408384 hasConcept C552990157 @default.
- W2046408384 hasConcept C55493867 @default.
- W2046408384 hasConcept C64241487 @default.
- W2046408384 hasConcept C73573662 @default.
- W2046408384 hasConcept C86803240 @default.
- W2046408384 hasConcept C96232424 @default.
- W2046408384 hasConceptScore W2046408384C104292427 @default.
- W2046408384 hasConceptScore W2046408384C104317684 @default.
- W2046408384 hasConceptScore W2046408384C121608353 @default.
- W2046408384 hasConceptScore W2046408384C134935766 @default.
- W2046408384 hasConceptScore W2046408384C143425029 @default.
- W2046408384 hasConceptScore W2046408384C184235292 @default.
- W2046408384 hasConceptScore W2046408384C185592680 @default.
- W2046408384 hasConceptScore W2046408384C194101687 @default.
- W2046408384 hasConceptScore W2046408384C2777844706 @default.
- W2046408384 hasConceptScore W2046408384C2778461978 @default.
- W2046408384 hasConceptScore W2046408384C2778502085 @default.
- W2046408384 hasConceptScore W2046408384C2779268695 @default.
- W2046408384 hasConceptScore W2046408384C2780258809 @default.
- W2046408384 hasConceptScore W2046408384C4710235 @default.
- W2046408384 hasConceptScore W2046408384C502942594 @default.
- W2046408384 hasConceptScore W2046408384C512185932 @default.
- W2046408384 hasConceptScore W2046408384C54355233 @default.
- W2046408384 hasConceptScore W2046408384C552990157 @default.
- W2046408384 hasConceptScore W2046408384C55493867 @default.
- W2046408384 hasConceptScore W2046408384C64241487 @default.
- W2046408384 hasConceptScore W2046408384C73573662 @default.
- W2046408384 hasConceptScore W2046408384C86803240 @default.
- W2046408384 hasConceptScore W2046408384C96232424 @default.
- W2046408384 hasLocation W20464083841 @default.
- W2046408384 hasOpenAccess W2046408384 @default.
- W2046408384 hasPrimaryLocation W20464083841 @default.
- W2046408384 hasRelatedWork W1964120744 @default.
- W2046408384 hasRelatedWork W1969955718 @default.
- W2046408384 hasRelatedWork W1970216768 @default.
- W2046408384 hasRelatedWork W1990443176 @default.
- W2046408384 hasRelatedWork W1995099674 @default.
- W2046408384 hasRelatedWork W2063278205 @default.
- W2046408384 hasRelatedWork W2322084736 @default.
- W2046408384 hasRelatedWork W2344857105 @default.
- W2046408384 hasRelatedWork W2578227239 @default.
- W2046408384 hasRelatedWork W2597985612 @default.
- W2046408384 hasRelatedWork W2604758836 @default.
- W2046408384 hasRelatedWork W2743992255 @default.
- W2046408384 hasRelatedWork W2777646502 @default.
- W2046408384 hasRelatedWork W2800617686 @default.
- W2046408384 hasRelatedWork W2909684532 @default.
- W2046408384 hasRelatedWork W2965966058 @default.
- W2046408384 hasRelatedWork W3083134305 @default.
- W2046408384 hasRelatedWork W3171949172 @default.
- W2046408384 hasRelatedWork W3213617400 @default.
- W2046408384 hasRelatedWork W2175564562 @default.
- W2046408384 isParatext "false" @default.
- W2046408384 isRetracted "false" @default.
- W2046408384 magId "2046408384" @default.
- W2046408384 workType "article" @default.