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- W2046409827 abstract "In the brain, on a macroscopic scale, diffusion of the intraneuronal constituent N-acetyl-L-aspartate (NAA) appears to be isotropic. In contrast, on a microscopic scale, NAA diffusion is likely highly anisotropic, with displacements perpendicular to neuronal fibers being markedly hindered, and parallel displacements less so. In this report we first substantiate that local anisotropy influences NAA diffusion in vivo by observing differing diffusivities parallel and perpendicular to human corpus callosum axonal fibers. We then extend our measurements to large voxels within rat brains. As expected, the macroscopic apparent diffusion coefficient (ADC) of NAA is practically isotropic due to averaging of the numerous and diverse fiber orientations. We demonstrate that the substantially non-monoexponential diffusion-mediated MR signal decay vs. b value can be quantitatively explained by a theoretical model of NAA confined to an ensemble of differently oriented neuronal fibers. On the microscopic scale, NAA diffusion is found to be strongly anisotropic, with displacements occurring almost exclusively parallel to the local fiber axis. This parallel diffusivity, ADC‖, is 0.36 ± 0.01 μm2/ms, and ADC⟂ is essentially zero. From ADC‖ the apparent viscosity of the neuron cytoplasm is estimated to be twice as large as that of a temperature-matched dilute aqueous solution. Magn Reson Med 52:1052–1059, 2004. © 2004 Wiley-Liss, Inc." @default.
- W2046409827 created "2016-06-24" @default.
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- W2046409827 date "2004-11-01" @default.
- W2046409827 modified "2023-10-17" @default.
- W2046409827 title "On the nature of the NAA diffusion attenuated MR signal in the central nervous system" @default.
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- W2046409827 doi "https://doi.org/10.1002/mrm.20260" @default.
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