FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046409929> ?p ?o ?g. }

• W2046409929 endingPage "299" @default.
• W2046409929 startingPage "294" @default.
• W2046409929 abstract "About 5–10% of the G protein-coupled receptors (GPCRs) contain N-terminal signal peptides that are cleaved off by the signal peptidases of the endoplasmic reticulum (ER) during the translocon-mediated receptor insertion into the ER membrane. The reason as to why only a subset of the GPCRs requires these additional signal peptides was addressed in the past decade only by a limited number of studies. Recent progress suggests that signal peptides of GPCRs do not only serve the classical ER targeting and translocon gating functions as described for the signal peptides of secretory proteins. In the case of GPCRs, uncleaved pseudo signal peptides may regulate receptor expression at the plasma membrane and may also influence G protein coupling. Moreover, signal peptides of GPCRs seem to match functionally with sequences of the mature N tails. In this review, we summarize the current knowledge about cleavable signal peptides of GPCRs and address the question whether these sequences may be future drug targets in pharmacology." @default.
• W2046409929 created "2016-06-24" @default.
• W2046409929 creator A5020668359 @default.
• W2046409929 creator A5023308750 @default.
• W2046409929 creator A5050518596 @default.
• W2046409929 creator A5059673448 @default.
• W2046409929 date "2012-04-01" @default.
• W2046409929 modified "2023-10-17" @default.
• W2046409929 title "Functional significance of cleavable signal peptides of G protein-coupled receptors" @default.
• W2046409929 cites W1605393199 @default.
• W2046409929 cites W163282153 @default.
• W2046409929 cites W171398818 @default.
• W2046409929 cites W179362953 @default.
• W2046409929 cites W1931242294 @default.
• W2046409929 cites W1966662743 @default.
• W2046409929 cites W1971447046 @default.
• W2046409929 cites W1973643925 @default.
• W2046409929 cites W1978218868 @default.
• W2046409929 cites W1998535769 @default.
• W2046409929 cites W2001734178 @default.
• W2046409929 cites W2002712119 @default.
• W2046409929 cites W2003934487 @default.
• W2046409929 cites W2018557658 @default.
• W2046409929 cites W2021288400 @default.
• W2046409929 cites W2022626941 @default.
• W2046409929 cites W2029387709 @default.
• W2046409929 cites W2030048671 @default.
• W2046409929 cites W2032686660 @default.
• W2046409929 cites W2040310721 @default.
• W2046409929 cites W2041903639 @default.
• W2046409929 cites W2042500117 @default.
• W2046409929 cites W2043844298 @default.
• W2046409929 cites W2047524608 @default.
• W2046409929 cites W2048813428 @default.
• W2046409929 cites W2049222500 @default.
• W2046409929 cites W2053951001 @default.
• W2046409929 cites W2056423986 @default.
• W2046409929 cites W2063371064 @default.
• W2046409929 cites W2069187419 @default.
• W2046409929 cites W2072854967 @default.
• W2046409929 cites W2073323005 @default.
• W2046409929 cites W2074005421 @default.
• W2046409929 cites W2100503817 @default.
• W2046409929 cites W2101947079 @default.
• W2046409929 cites W2109014958 @default.
• W2046409929 cites W2116140901 @default.
• W2046409929 cites W2118016880 @default.
• W2046409929 cites W2128207929 @default.
• W2046409929 cites W2130159500 @default.
• W2046409929 cites W2138794487 @default.
• W2046409929 cites W2145716707 @default.
• W2046409929 cites W2145784506 @default.
• W2046409929 cites W2148984531 @default.
• W2046409929 cites W2155611012 @default.
• W2046409929 cites W2156574575 @default.
• W2046409929 cites W2157377535 @default.
• W2046409929 cites W2157959080 @default.
• W2046409929 cites W2161746138 @default.
• W2046409929 cites W2162824898 @default.
• W2046409929 cites W2164282000 @default.
• W2046409929 cites W2171091522 @default.
• W2046409929 cites W2217392873 @default.
• W2046409929 cites W2951053303 @default.
• W2046409929 doi "https://doi.org/10.1016/j.ejcb.2011.02.006" @default.
• W2046409929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21543132" @default.
• W2046409929 hasPublicationYear "2012" @default.
• W2046409929 type Work @default.
• W2046409929 sameAs 2046409929 @default.
• W2046409929 citedByCount "26" @default.
• W2046409929 countsByYear W20464099292012 @default.
• W2046409929 countsByYear W20464099292013 @default.
• W2046409929 countsByYear W20464099292014 @default.
• W2046409929 countsByYear W20464099292015 @default.
• W2046409929 countsByYear W20464099292016 @default.
• W2046409929 countsByYear W20464099292017 @default.
• W2046409929 countsByYear W20464099292018 @default.
• W2046409929 countsByYear W20464099292019 @default.
• W2046409929 countsByYear W20464099292020 @default.
• W2046409929 countsByYear W20464099292021 @default.
• W2046409929 countsByYear W20464099292023 @default.
• W2046409929 crossrefType "journal-article" @default.
• W2046409929 hasAuthorship W2046409929A5020668359 @default.
• W2046409929 hasAuthorship W2046409929A5023308750 @default.
• W2046409929 hasAuthorship W2046409929A5050518596 @default.
• W2046409929 hasAuthorship W2046409929A5059673448 @default.
• W2046409929 hasConcept C104317684 @default.
• W2046409929 hasConcept C10858879 @default.
• W2046409929 hasConcept C135285700 @default.
• W2046409929 hasConcept C144647389 @default.
• W2046409929 hasConcept C158617107 @default.
• W2046409929 hasConcept C167625842 @default.
• W2046409929 hasConcept C170493617 @default.
• W2046409929 hasConcept C199229279 @default.
• W2046409929 hasConcept C2779190341 @default.
• W2046409929 hasConcept C41625074 @default.
• W2046409929 hasConcept C55493867 @default.
• W2046409929 hasConcept C559089031 @default.
• W2046409929 hasConcept C86803240 @default.

• next