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- W2046412912 abstract "Abstract Chicken cells were transformed with helper-independent avian sarcoma viruses, subgroup C and D, respectively. The DNA extracted from these cells gave rise, in infectivity assays, to both transforming and transformation-defective viruses. Both viruses were recovered with a similar frequency at the end-point dilution (0.05 μg DNA per 10 7 cells) of infectious DNA. Increasing the DNA concentration had little influence on the probability of successful recovery of a sarcoma virus. On the other hand, the probability of recovering a transformation-defective virus increased when chicken cells received higher concentrations of DNA. Transformation-defective viruses here recovered for the first time after transfection with DNA from RSV-transformed cells were further investigated. Interference assays showed that these transformation-defective viruses interfered with sarcoma viruses recovered with the same DNA or belonging to the same antigenic subgroup as the DNA parent. No interference was encountered between viruses produced with infectious DNAs of antigenically different parents. Interference patterns of a cloned transforming virus suggested that the transforming viral DNA progeny was independent of a helper virus. Both transformation-defective and transforming viruses possessed the same buoyant density of 1.168 g/cm 3 . Viral RNA of the transformation-defective viruses sedimented slower than that of the transforming virus, the sedimentation coefficients being 65 S and 71 S, respectively. In distinction to the sarcoma virus, a transformation-defective isolate did not give rise to tumors in bioassays. Chicken cells infected with the transformation-defective virus harbored infectious DNA which produced transformation-defective viruses in infectivity assays but was unable to generate a sarcoma virus. A transformation-defective virus isolated in these infections interfered with its sarcomatogenous ancestor. To explain these results it is suggested that RSV-transformed chicken cells may carry two species of infectious DNA belonging to the sarcoma virus and its transformation-defective segregant, respectively. RSV-transformed mammalian cells appear to harbor only sarcoma viral DNA." @default.
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- W2046412912 date "1974-11-01" @default.
- W2046412912 modified "2023-10-17" @default.
- W2046412912 title "Sarcoma and transformation-defective viruses produced with infectious DNA(s) from Rous sarcoma virus (RSV)-transformed chicken cells" @default.
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- W2046412912 doi "https://doi.org/10.1016/0042-6822(74)90315-8" @default.
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