Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046421277> ?p ?o ?g. }
- W2046421277 endingPage "26" @default.
- W2046421277 startingPage "15" @default.
- W2046421277 abstract "To explore the therapeutic potential of copper-based benzimidazole complexes, tetranuclear Cu(II) complex 1 and dinuclear ternary amino acid complexes 2 and 3 {L-trp and L-val, respectively} were synthesized and thoroughly characterized. In vitro DNA binding studies of complexes 1-3 were carried out employing UV-vis titrations, fluorescence, circular dichroic and viscosity measurements which revealed that the complexes 1-3 bind to CT DNA preferably via groove binding. Complex 1 cleaved pBR322 DNA via hydrolytic pathway (validated by T4 DNA ligase assay), accessible to major groove while 2 followed oxidative mechanism, binding to minor groove of DNA double helix; binding events were further validated by molecular docking studies. Additionally, the complexes 1 and 2 exhibit high Topo-I inhibitory activity at different concentrations. The complexes 1-3 were evaluated for antibacterial activity against Escherichia coli and Staphylococcus aureus, and 2 was found to be most effective against Gram-positive bacteria." @default.
- W2046421277 created "2016-06-24" @default.
- W2046421277 creator A5009713147 @default.
- W2046421277 creator A5045163988 @default.
- W2046421277 creator A5086366057 @default.
- W2046421277 creator A5090737758 @default.
- W2046421277 date "2012-09-01" @default.
- W2046421277 modified "2023-09-22" @default.
- W2046421277 title "Synthesis, characterization, biological studies (DNA binding, cleavage, antibacterial and topoisomerase I) and molecular docking of copper(II) benzimidazole complexes" @default.
- W2046421277 cites W1965732856 @default.
- W2046421277 cites W1967006545 @default.
- W2046421277 cites W1967227734 @default.
- W2046421277 cites W1967627122 @default.
- W2046421277 cites W1969612501 @default.
- W2046421277 cites W1972310517 @default.
- W2046421277 cites W1980324181 @default.
- W2046421277 cites W1984766458 @default.
- W2046421277 cites W1989321011 @default.
- W2046421277 cites W1994492355 @default.
- W2046421277 cites W1995378615 @default.
- W2046421277 cites W1997116722 @default.
- W2046421277 cites W2000866464 @default.
- W2046421277 cites W2000982551 @default.
- W2046421277 cites W2001297648 @default.
- W2046421277 cites W2001581340 @default.
- W2046421277 cites W2005948990 @default.
- W2046421277 cites W2009696322 @default.
- W2046421277 cites W2012775604 @default.
- W2046421277 cites W2017389844 @default.
- W2046421277 cites W2019193728 @default.
- W2046421277 cites W2019725236 @default.
- W2046421277 cites W2020185571 @default.
- W2046421277 cites W2030128366 @default.
- W2046421277 cites W2035263948 @default.
- W2046421277 cites W2036213136 @default.
- W2046421277 cites W2038124483 @default.
- W2046421277 cites W2040184556 @default.
- W2046421277 cites W2044244175 @default.
- W2046421277 cites W2044851985 @default.
- W2046421277 cites W2046715555 @default.
- W2046421277 cites W2048645097 @default.
- W2046421277 cites W2049610599 @default.
- W2046421277 cites W2049832563 @default.
- W2046421277 cites W2059179362 @default.
- W2046421277 cites W2060415159 @default.
- W2046421277 cites W2060680862 @default.
- W2046421277 cites W2063881867 @default.
- W2046421277 cites W2067829883 @default.
- W2046421277 cites W2081386568 @default.
- W2046421277 cites W2085183831 @default.
- W2046421277 cites W2087752336 @default.
- W2046421277 cites W2088476033 @default.
- W2046421277 cites W2088695864 @default.
- W2046421277 cites W2089219339 @default.
- W2046421277 cites W2089459455 @default.
- W2046421277 cites W2090637389 @default.
- W2046421277 cites W2095226203 @default.
- W2046421277 cites W2103845650 @default.
- W2046421277 cites W2108226564 @default.
- W2046421277 cites W2108885056 @default.
- W2046421277 cites W2117471032 @default.
- W2046421277 cites W2132444809 @default.
- W2046421277 cites W2168161803 @default.
- W2046421277 cites W2221047551 @default.
- W2046421277 cites W2324613566 @default.
- W2046421277 cites W2411870621 @default.
- W2046421277 cites W2953285484 @default.
- W2046421277 cites W3022230571 @default.
- W2046421277 cites W4245397386 @default.
- W2046421277 cites W7243943 @default.
- W2046421277 doi "https://doi.org/10.1016/j.jphotobiol.2012.05.003" @default.
- W2046421277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22695227" @default.
- W2046421277 hasPublicationYear "2012" @default.
- W2046421277 type Work @default.
- W2046421277 sameAs 2046421277 @default.
- W2046421277 citedByCount "123" @default.
- W2046421277 countsByYear W20464212772012 @default.
- W2046421277 countsByYear W20464212772013 @default.
- W2046421277 countsByYear W20464212772014 @default.
- W2046421277 countsByYear W20464212772015 @default.
- W2046421277 countsByYear W20464212772016 @default.
- W2046421277 countsByYear W20464212772017 @default.
- W2046421277 countsByYear W20464212772018 @default.
- W2046421277 countsByYear W20464212772019 @default.
- W2046421277 countsByYear W20464212772020 @default.
- W2046421277 countsByYear W20464212772021 @default.
- W2046421277 countsByYear W20464212772022 @default.
- W2046421277 countsByYear W20464212772023 @default.
- W2046421277 crossrefType "journal-article" @default.
- W2046421277 hasAuthorship W2046421277A5009713147 @default.
- W2046421277 hasAuthorship W2046421277A5045163988 @default.
- W2046421277 hasAuthorship W2046421277A5086366057 @default.
- W2046421277 hasAuthorship W2046421277A5090737758 @default.
- W2046421277 hasConcept C147897179 @default.
- W2046421277 hasConcept C159110408 @default.
- W2046421277 hasConcept C175114707 @default.
- W2046421277 hasConcept C178790620 @default.
- W2046421277 hasConcept C185592680 @default.