Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046434476> ?p ?o ?g. }
- W2046434476 endingPage "e163" @default.
- W2046434476 startingPage "e144" @default.
- W2046434476 abstract "Tendon/ligament injuries are very common in sports and other rigorous activities. Tendons regenerate and repair slowly and inefficiently in vivo after injury. The limited ability of tendon to self-repair and the general inefficiencies of current treatment regimes have hastened the motivation to develop tissue-engineering strategies for tissue repair. Of particular interest in recent years has been the use of adult mesenchymal stem cells (MSCs) to regenerate functional tendons and ligaments. Different sources of MSCs have been studied for their effects on tendon repair. However, ectopic bone and tumour formation has been reported in some special circumstances after transplantation of MSCs. The induction of MSCs to differentiate into tendon-forming cells in vitro prior to transplantation is a possible approach to avoid ectopic bone and tumour formation while promoting tendon repair. While there are reports about the factors that might promote tenogenic differentiation, the study of tenogenic differentiation is hampered by the lack of definitive biomarkers for tendons. This review aims to summarize the cell sources currently used for tendon repair as well as their advantages and limitations. Factors affecting tenogenic differentiation were summarized. Molecular markers currently used for assessing tenogenic differentiation or neotendon formation are summarized and their advantages and limitations are commented upon. Finally, further directions for promoting and assessing tenogenic differentiation of stem cells for tendon repair are discussed. Copyright © 2011 John Wiley & Sons, Ltd." @default.
- W2046434476 created "2016-06-24" @default.
- W2046434476 creator A5022289738 @default.
- W2046434476 creator A5029730758 @default.
- W2046434476 creator A5030872921 @default.
- W2046434476 creator A5031855156 @default.
- W2046434476 date "2011-05-05" @default.
- W2046434476 modified "2023-10-14" @default.
- W2046434476 title "Tenogenic differentiation of stem cells for tendon repair-what is the current evidence?" @default.
- W2046434476 cites W1546183147 @default.
- W2046434476 cites W1748492751 @default.
- W2046434476 cites W1937780100 @default.
- W2046434476 cites W1952078600 @default.
- W2046434476 cites W1963698480 @default.
- W2046434476 cites W1963698651 @default.
- W2046434476 cites W1964368920 @default.
- W2046434476 cites W1964831428 @default.
- W2046434476 cites W1964938903 @default.
- W2046434476 cites W1968145647 @default.
- W2046434476 cites W1971912560 @default.
- W2046434476 cites W1973008018 @default.
- W2046434476 cites W1974106192 @default.
- W2046434476 cites W1974686435 @default.
- W2046434476 cites W1975599224 @default.
- W2046434476 cites W1978005832 @default.
- W2046434476 cites W1983268178 @default.
- W2046434476 cites W1984842341 @default.
- W2046434476 cites W1986300999 @default.
- W2046434476 cites W1986917953 @default.
- W2046434476 cites W1987047331 @default.
- W2046434476 cites W1988106932 @default.
- W2046434476 cites W1991096907 @default.
- W2046434476 cites W1991964705 @default.
- W2046434476 cites W1992245888 @default.
- W2046434476 cites W1995122819 @default.
- W2046434476 cites W1995383666 @default.
- W2046434476 cites W1997617677 @default.
- W2046434476 cites W2000156083 @default.
- W2046434476 cites W2000400813 @default.
- W2046434476 cites W2000488306 @default.
- W2046434476 cites W2001467937 @default.
- W2046434476 cites W2001895901 @default.
- W2046434476 cites W2003251092 @default.
- W2046434476 cites W2005463323 @default.
- W2046434476 cites W2011736517 @default.
- W2046434476 cites W2012222854 @default.
- W2046434476 cites W2015252829 @default.
- W2046434476 cites W2015979204 @default.
- W2046434476 cites W2017564586 @default.
- W2046434476 cites W2019109358 @default.
- W2046434476 cites W2019660345 @default.
- W2046434476 cites W2019989758 @default.
- W2046434476 cites W2020280797 @default.
- W2046434476 cites W2021434323 @default.
- W2046434476 cites W2023436570 @default.
- W2046434476 cites W2024662362 @default.
- W2046434476 cites W2024894752 @default.
- W2046434476 cites W2025182546 @default.
- W2046434476 cites W2025916992 @default.
- W2046434476 cites W2029002097 @default.
- W2046434476 cites W2029181640 @default.
- W2046434476 cites W2029935659 @default.
- W2046434476 cites W2030488779 @default.
- W2046434476 cites W2031280537 @default.
- W2046434476 cites W2032652535 @default.
- W2046434476 cites W2033080243 @default.
- W2046434476 cites W2033162091 @default.
- W2046434476 cites W2037744155 @default.
- W2046434476 cites W2039245785 @default.
- W2046434476 cites W2040438302 @default.
- W2046434476 cites W2041207935 @default.
- W2046434476 cites W2041518387 @default.
- W2046434476 cites W2045294249 @default.
- W2046434476 cites W2045946031 @default.
- W2046434476 cites W2046309513 @default.
- W2046434476 cites W2049958856 @default.
- W2046434476 cites W2049968553 @default.
- W2046434476 cites W2050192868 @default.
- W2046434476 cites W2050709784 @default.
- W2046434476 cites W2054895108 @default.
- W2046434476 cites W2055358063 @default.
- W2046434476 cites W2056274633 @default.
- W2046434476 cites W2056837339 @default.
- W2046434476 cites W2057400150 @default.
- W2046434476 cites W2057544864 @default.
- W2046434476 cites W2059128992 @default.
- W2046434476 cites W2062323603 @default.
- W2046434476 cites W2063463470 @default.
- W2046434476 cites W2063872591 @default.
- W2046434476 cites W2067759661 @default.
- W2046434476 cites W2073968937 @default.
- W2046434476 cites W2074300383 @default.
- W2046434476 cites W2078053702 @default.
- W2046434476 cites W2079280255 @default.
- W2046434476 cites W2081595374 @default.
- W2046434476 cites W2081791895 @default.
- W2046434476 cites W2081854922 @default.
- W2046434476 cites W2082210002 @default.