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- W2046436404 abstract "Abstract The purpose of our study was to evaluate the correlation between expression of VEGF, HIF-1α, E-cadherin, and p53 and pathologic stage. We retrospectively reviewed the medical records of the 101 patients who underwent surgery of thyroid nodules from 2000 to 2007. Expression of VEGF, HIF-1α, E-cadherin, and p53 were examinated immunohistochemically. Papillary thyroid carcinoma in this study included 54 cases of more than 45 years old. Each expression of VEGF, HIF-1α, E-cadherin, and p53 was analysed. Only expression loss of E-cadherin was associated with the stage. High HIF-1 expression was significantly associated with VEGF immunoreactivity (p＜0.05). Expression loss of E-cadherin was independent unfavorable factors. It is suggested that high HIF-1α expression may be associated with intratumoral neovascularization possibly through HIF-VEGF pathway. Key Words : Papillary Thyroid Carcinoma, VEGF, HIF-1α, E-Cadherin, p53 * 교신저자 : 나백주(skqw@konyang.ac.kr)접수일 09년 07월 16일 수정일 (1차 09년 12월 09일, 2차 10년 01월 07일) 게재확정일 10년 03월 18일" @default.
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- W2046436404 date "2010-03-31" @default.
- W2046436404 modified "2023-09-27" @default.
- W2046436404 title "Relationship between the Expression of VEGF, HIF-1α, E-cadherin, p53 and Stage in Papillary Thyroid Carcinoma" @default.
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- W2046436404 doi "https://doi.org/10.5762/kais.2010.11.3.1133" @default.
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