Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046447102> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2046447102 endingPage "124" @default.
- W2046447102 startingPage "117" @default.
- W2046447102 abstract "Sodium salts are often used in drug formulation but their partial solubility parameters are not available. Sodium alters the physical properties of the drug and the knowledge of these parameters would help to predict adhesion properties that cannot be estimated using the solubility parameters of the parent acid. This work tests the applicability of the modified extended Hansen method to determine partial solubility parameters of sodium salts of acidic drugs containing a single hydrogen bonding group (ibuprofen, sodium ibuprofen, benzoic acid and sodium benzoate). The method uses a regression analysis of the logarithm of the experimental mole fraction solubility of the drug against the partial solubility parameters of the solvents, using models with three and four parameters. The solubility of the drugs was determined in a set of solvents representative of several chemical classes, ranging from low to high solubility parameter values. The best results were obtained with the four parameter model for the acidic drugs and with the three parameter model for the sodium derivatives. The four parameter model includes both a Lewis-acid and a Lewis-base term. Since the Lewis acid properties of the sodium derivatives are blocked by sodium, the three parameter model is recommended for these kind of compounds. Comparison of the parameters obtained shows that sodium greatly changes the polar parameters whereas the dispersion parameter is not much affected. Consequently the total solubility parameters of the salts are larger than for the parent acids in good agreement with the larger hydrophilicity expected from the introduction of sodium. The results indicate that the modified extended Hansen method can be applied to determine the partial solubility parameters of acidic drugs and their sodium salts." @default.
- W2046447102 created "2016-06-24" @default.
- W2046447102 creator A5032133507 @default.
- W2046447102 creator A5075363720 @default.
- W2046447102 creator A5084566741 @default.
- W2046447102 date "2000-01-01" @default.
- W2046447102 modified "2023-09-23" @default.
- W2046447102 title "The modified extended Hansen method to determine partial solubility parameters of drugs containing a single hydrogen bonding group and their sodium derivatives: benzoic acid/Na and ibuprofen/Na" @default.
- W2046447102 cites W1479682365 @default.
- W2046447102 cites W2001250900 @default.
- W2046447102 cites W2022702266 @default.
- W2046447102 cites W2024704818 @default.
- W2046447102 cites W2038824808 @default.
- W2046447102 cites W2059243437 @default.
- W2046447102 cites W2066324113 @default.
- W2046447102 cites W2070654806 @default.
- W2046447102 cites W2073389266 @default.
- W2046447102 cites W2139507475 @default.
- W2046447102 cites W2164214880 @default.
- W2046447102 doi "https://doi.org/10.1016/s0378-5173(99)00374-9" @default.
- W2046447102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10601690" @default.
- W2046447102 hasPublicationYear "2000" @default.
- W2046447102 type Work @default.
- W2046447102 sameAs 2046447102 @default.
- W2046447102 citedByCount "66" @default.
- W2046447102 countsByYear W20464471022012 @default.
- W2046447102 countsByYear W20464471022013 @default.
- W2046447102 countsByYear W20464471022014 @default.
- W2046447102 countsByYear W20464471022015 @default.
- W2046447102 countsByYear W20464471022017 @default.
- W2046447102 countsByYear W20464471022018 @default.
- W2046447102 countsByYear W20464471022019 @default.
- W2046447102 countsByYear W20464471022020 @default.
- W2046447102 countsByYear W20464471022021 @default.
- W2046447102 countsByYear W20464471022022 @default.
- W2046447102 countsByYear W20464471022023 @default.
- W2046447102 crossrefType "journal-article" @default.
- W2046447102 hasAuthorship W2046447102A5032133507 @default.
- W2046447102 hasAuthorship W2046447102A5075363720 @default.
- W2046447102 hasAuthorship W2046447102A5084566741 @default.
- W2046447102 hasConcept C100293340 @default.
- W2046447102 hasConcept C155574463 @default.
- W2046447102 hasConcept C178790620 @default.
- W2046447102 hasConcept C185592680 @default.
- W2046447102 hasConcept C2777574038 @default.
- W2046447102 hasConcept C2778844314 @default.
- W2046447102 hasConcept C2779944601 @default.
- W2046447102 hasConcept C31903555 @default.
- W2046447102 hasConcept C537181965 @default.
- W2046447102 hasConcept C71924100 @default.
- W2046447102 hasConcept C98274493 @default.
- W2046447102 hasConceptScore W2046447102C100293340 @default.
- W2046447102 hasConceptScore W2046447102C155574463 @default.
- W2046447102 hasConceptScore W2046447102C178790620 @default.
- W2046447102 hasConceptScore W2046447102C185592680 @default.
- W2046447102 hasConceptScore W2046447102C2777574038 @default.
- W2046447102 hasConceptScore W2046447102C2778844314 @default.
- W2046447102 hasConceptScore W2046447102C2779944601 @default.
- W2046447102 hasConceptScore W2046447102C31903555 @default.
- W2046447102 hasConceptScore W2046447102C537181965 @default.
- W2046447102 hasConceptScore W2046447102C71924100 @default.
- W2046447102 hasConceptScore W2046447102C98274493 @default.
- W2046447102 hasIssue "1" @default.
- W2046447102 hasLocation W20464471021 @default.
- W2046447102 hasLocation W20464471022 @default.
- W2046447102 hasOpenAccess W2046447102 @default.
- W2046447102 hasPrimaryLocation W20464471021 @default.
- W2046447102 hasRelatedWork W1976606316 @default.
- W2046447102 hasRelatedWork W1981078983 @default.
- W2046447102 hasRelatedWork W2004156263 @default.
- W2046447102 hasRelatedWork W2024704818 @default.
- W2046447102 hasRelatedWork W2038824808 @default.
- W2046447102 hasRelatedWork W2046447102 @default.
- W2046447102 hasRelatedWork W2189298918 @default.
- W2046447102 hasRelatedWork W2379371893 @default.
- W2046447102 hasRelatedWork W2774159251 @default.
- W2046447102 hasRelatedWork W2787543480 @default.
- W2046447102 hasVolume "194" @default.
- W2046447102 isParatext "false" @default.
- W2046447102 isRetracted "false" @default.
- W2046447102 magId "2046447102" @default.
- W2046447102 workType "article" @default.