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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046452017> ?p ?o ?g. }

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• W2046452017 abstract "The hypothesis that intense stimulation of NMDA receptors activates calpain was tested in long-term cultures of hippocampus. Slices prepared from 10-day-old rats were maintained for periods of up to 6 weeks and then assayed for a stable breakdown product that results from the proteolysis of spectrin by calpain. The breakdown product increased dramatically during the first 24 h after tissue preparation and then decreased to a low level that remained unchanged for weeks. NMDA caused a 2- to 3-fold increase in breakdown product that rose linearly with time (5-30 min) and was blocked by the receptor antagonist MK-801. The effect of NMDA was the same throughout the culture period and was dependent upon the concentration of extracellular calcium with no effect at 2 mM and maximal effect at 4 mM calcium. These results indicate that rapid activation of calpain occurs in undamaged hippocampal neurons following stimulation of NMDA receptors." @default.
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• W2046452017 date "1994-02-01" @default.
• W2046452017 modified "2023-09-26" @default.
• W2046452017 title "Stimulation of NMDA receptors activates calpain in cultured hippocampal slices" @default.
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• W2046452017 doi "https://doi.org/10.1016/0304-3940(94)91049-9" @default.
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