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• W2046452642 abstract "ABSTRACT Synthesis, solid state characterization and anti HIV-1 activity of 3′-azido-3′-deoxy-5′-O-isonicotinoylthymidine (2), a new prodrug of zidovudine (AZT, 1), are described. Two solid forms of 2 prepared by crystallization from ethyl acetate-petroleum ether (form α) and from a melt sample of form α (amorphous form) were characterized by X-ray diffractometry, infrared spectroscopy, differential scanning calorimetry (DSC) and thermogravimetry (TGA) techniques. The novel nucleoside exhibited antiviral activity against standard and resistant strain panels of HIV-1 as well as cytotoxicity similar to that of AZT." @default.
• W2046452642 created "2016-06-24" @default.
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• W2046452642 date "2002-04-15" @default.
• W2046452642 modified "2023-10-03" @default.
• W2046452642 title "3′-AZIDO-3′-DEOXY-5′-O-ISONICOTINOYLTHYMIDINE, A NEW PRODRUG OF ZIDOVUDINE. SYNTHESIS, SOLID STATE CHARACTERIZATION AND ANTI HIV-1 ACTIVITY" @default.
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• W2046452642 doi "https://doi.org/10.1081/ncn-120003287" @default.
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