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- W2046453586 abstract "Acute liver injury can develop as a consequence of viral hepatitis, drug- or toxin-induced toxicity or rejection after liver transplantation, whereas chronic liver injury can be due to long-term exposure to alcohol, chemicals, chronic viral hepatitis, metabolic or cholestatic disorders. During liver injury, liver cells are exposed to increased levels of cytokines, bile acids and oxidative stress. This results in death of hepatocytes. In contrast, stellate cells become active and are resistant against cell death. Eventually, acute and chronic liver injury is followed by loss of liver function for which no effective therapies are available. Hepatocytes are well equipped with protective mechanisms to prevent cell death. As long as these protective mechanisms can be activated, the balance will be in favour of cell survival. However, the balance between cell survival and cell death is delicate and can be easily tipped towards cell death during liver injury. Therefore understanding the cellular mechanisms controlling death of liver cells is of clinical and scientific importance and can lead to the identification of novel intervention targets. This review describes some of the mechanisms that determine the balance between cell death and cell survival during liver diseases. The strict regulation of apoptotic cell death allows therapeutic intervention strategies. In this light, receptor-mediated apoptosis and mitochondria-mediated cell death are discussed and strategies are provided to selectively interfere with these processes." @default.
- W2046453586 created "2016-06-24" @default.
- W2046453586 creator A5043968888 @default.
- W2046453586 creator A5061934939 @default.
- W2046453586 date "2004-06-23" @default.
- W2046453586 modified "2023-09-23" @default.
- W2046453586 title "Defying death: the hepatocyte's survival kit" @default.
- W2046453586 cites W12631990 @default.
- W2046453586 cites W1266590697 @default.
- W2046453586 cites W1492606093 @default.
- W2046453586 cites W1500396877 @default.
- W2046453586 cites W1513790829 @default.
- W2046453586 cites W1549679997 @default.
- W2046453586 cites W1593219141 @default.
- W2046453586 cites W163606371 @default.
- W2046453586 cites W1641228030 @default.
- W2046453586 cites W1888783223 @default.
- W2046453586 cites W1973109581 @default.
- W2046453586 cites W1974303227 @default.
- W2046453586 cites W1976913110 @default.
- W2046453586 cites W1978880070 @default.
- W2046453586 cites W1979998867 @default.
- W2046453586 cites W1983398917 @default.
- W2046453586 cites W1984061256 @default.
- W2046453586 cites W1984547206 @default.
- W2046453586 cites W1988355439 @default.
- W2046453586 cites W1991384293 @default.
- W2046453586 cites W1994144074 @default.
- W2046453586 cites W1996405087 @default.
- W2046453586 cites W1996907401 @default.
- W2046453586 cites W1997275067 @default.
- W2046453586 cites W1998195373 @default.
- W2046453586 cites W2000446104 @default.
- W2046453586 cites W2000601138 @default.
- W2046453586 cites W2001545207 @default.
- W2046453586 cites W2001991668 @default.
- W2046453586 cites W2002127663 @default.
- W2046453586 cites W2003137211 @default.
- W2046453586 cites W2004388628 @default.
- W2046453586 cites W2005141055 @default.
- W2046453586 cites W2005449077 @default.
- W2046453586 cites W2006012100 @default.
- W2046453586 cites W2006652614 @default.
- W2046453586 cites W2007127627 @default.
- W2046453586 cites W2007456787 @default.
- W2046453586 cites W2011974399 @default.
- W2046453586 cites W2012668509 @default.
- W2046453586 cites W2014026862 @default.
- W2046453586 cites W2014717081 @default.
- W2046453586 cites W2015193975 @default.
- W2046453586 cites W2015965270 @default.
- W2046453586 cites W2016223901 @default.
- W2046453586 cites W2017102177 @default.
- W2046453586 cites W2019369579 @default.
- W2046453586 cites W2020321505 @default.
- W2046453586 cites W2021413266 @default.
- W2046453586 cites W2021545961 @default.
- W2046453586 cites W2023073081 @default.
- W2046453586 cites W2023252159 @default.
- W2046453586 cites W2023826691 @default.
- W2046453586 cites W2024758605 @default.
- W2046453586 cites W2026482903 @default.
- W2046453586 cites W2027376217 @default.
- W2046453586 cites W2031643961 @default.
- W2046453586 cites W2032383673 @default.
- W2046453586 cites W2034213169 @default.
- W2046453586 cites W2041484374 @default.
- W2046453586 cites W2041827858 @default.
- W2046453586 cites W2042409437 @default.
- W2046453586 cites W2044608904 @default.
- W2046453586 cites W2045175932 @default.
- W2046453586 cites W2046111632 @default.
- W2046453586 cites W2047293885 @default.
- W2046453586 cites W2049420147 @default.
- W2046453586 cites W2051021690 @default.
- W2046453586 cites W2051258629 @default.
- W2046453586 cites W2053467011 @default.
- W2046453586 cites W2055012522 @default.
- W2046453586 cites W2056647420 @default.
- W2046453586 cites W2057718962 @default.
- W2046453586 cites W2062807784 @default.
- W2046453586 cites W2062853648 @default.
- W2046453586 cites W2065322133 @default.
- W2046453586 cites W2065540066 @default.
- W2046453586 cites W2066615574 @default.
- W2046453586 cites W2069585529 @default.
- W2046453586 cites W2070885630 @default.
- W2046453586 cites W2072756792 @default.
- W2046453586 cites W2073976519 @default.
- W2046453586 cites W2075477970 @default.
- W2046453586 cites W2079935897 @default.
- W2046453586 cites W2081360317 @default.
- W2046453586 cites W2083537936 @default.
- W2046453586 cites W2083701361 @default.
- W2046453586 cites W2083906562 @default.
- W2046453586 cites W2084223046 @default.
- W2046453586 cites W2084506111 @default.
- W2046453586 cites W2086391747 @default.