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- W2046456420 endingPage "498" @default.
- W2046456420 startingPage "479" @default.
- W2046456420 abstract "Summry— Deregulation of gene expression is a hallmark of the cancer cell. Acquiring a new profile of expressed proteins may enable the cell to re-enter the cell cycle, or give them a growth or motility advantage over “normal cells”. An efficient and rapid way to alter gene expression is via regulation of mRNAs already transcribed. Modifications of mRNA stability and/or translational efficiency are increasingly reported in cancer. mRNA stability and translation are controlled through a complex network of RNA/protein interactions involving recognition of specific target mRNAs by RNA-BPs. We review how alterations in regulatory sequences, RNA-BPs, or in upstream signalling pathways affect the stability and/or translational efficiency of mRNAs encoding proto-oncogenes, cytokines, cell cycle regulators and other regulatory proteins to promote tumorigenesis and cancer progression. A more thorough understanding of post-transcriptional mechanisms such as these will enable the design and development of specific therapies based on modulating the translation or stability of specific mRNAs." @default.
- W2046456420 created "2016-06-24" @default.
- W2046456420 creator A5037770228 @default.
- W2046456420 creator A5054186146 @default.
- W2046456420 date "2004-09-01" @default.
- W2046456420 modified "2023-10-14" @default.
- W2046456420 title "Post-transcriptional regulation in cancer" @default.
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