FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046457770> ?p ?o ?g. }

• W2046457770 endingPage "346" @default.
• W2046457770 startingPage "342" @default.
• W2046457770 abstract "Increased free fatty acid (FFA) levels of obese patients are likely involved in the pathogenesis of the growth hormone (GH) hyposecretion of obesity. To clarify their role, we studied the influence of inhibition of plasma FFA levels, induced by 500 mg oral acipimox (ACX), an antilipolytic drug, on the GH response to GH-releasing hormone (GHRH) alone or combined with arginine ([ARG] study A) in six normal women ([NS] aged 24 to 37 years; body mass index, 22.4 ± 0.9 kg/m2) and six obese women ([OB] aged 21 to 40 years; body mass index, 39.5 ± 3.2 kg/m2). In a group of seven OB patients (aged 18 to 58 years; body mass index, 35.8 ± 1.3 kg/m2), the effect of ACX on either the GHRH- or GHRH+ARG-stimulated GH increase was also studied after a 4-day treatment with the same drug at 250 mg three times daily (study B). OB patients had baseline FFA levels higher than NS (0.77 ± 0.06 v 0.44 ± 0.09 mol/L, P < .05). In study A, ACX reduced FFA levels to the same nadir in both groups (0.11 ± 0.02 and 0.12 ± 0.03 mmol/L, NS and OB subjects, respectively). In NS, ACX failed to significantly potentiate the GH response to either GHRH (1,371.9 ± 425.2 v 1,001.8 ± 229.0 μg/L · min) or GHRH+ARG (3,558.4 ± 1,513.7 v 3,045.9 ± 441.8 μg/L · min), while in OB patients it increased the GH response to GHRH (797.6 ± 277.3 v 353.8 ± 136.7 μg/L · min, P < .01) and did not modify the response to ARG+GHRH (1,010.5 ± 253.1 v 821.1 ± 222.0 μg/L · min). In study B, ACX reduced FFA levels in OB patients (nadir, 0.09 ± 0.04 mmol/L). This treatment strikingly increased the GH response to GHRH (1,734.0 ± 725.4 v 271.5 ± 112.8 μg/L · min, P < .01) and significantly potentiated that to ARG+GHRH (2,371.9 ± 571.3 v 1,020.0 ± 343.2 μg/L · min, P < .05). In conclusion, our present findings indicate that an acute reduction of plasma FFA levels in OB patients restores their somatotrope responsiveness, whereas it does not affect GH secretion in lean subjects. After prolonged treatment, ACX further improves GHRH-stimulated GH secretion in OB patients, suggesting that elevated FFA levels play a leading role in the GH hyposecretory state of obesity." @default.
• W2046457770 created "2016-06-24" @default.
• W2046457770 creator A5007907892 @default.
• W2046457770 creator A5016794850 @default.
• W2046457770 creator A5038835910 @default.
• W2046457770 creator A5048030797 @default.
• W2046457770 creator A5056162271 @default.
• W2046457770 creator A5057537921 @default.
• W2046457770 creator A5085189039 @default.
• W2046457770 creator A5090420431 @default.
• W2046457770 date "1996-03-01" @default.
• W2046457770 modified "2023-10-16" @default.
• W2046457770 title "Effects of acipimox, an antilipolytic drug, on the growth hormone (GH) response to GH-releasing hormone alone or combined with arginine in obesity" @default.
• W2046457770 cites W1970957863 @default.
• W2046457770 cites W1977319021 @default.
• W2046457770 cites W1978744281 @default.
• W2046457770 cites W1982478568 @default.
• W2046457770 cites W2000349916 @default.
• W2046457770 cites W2005382240 @default.
• W2046457770 cites W2005693445 @default.
• W2046457770 cites W2010965342 @default.
• W2046457770 cites W2029107159 @default.
• W2046457770 cites W2035101457 @default.
• W2046457770 cites W2036195882 @default.
• W2046457770 cites W2040058909 @default.
• W2046457770 cites W2040920498 @default.
• W2046457770 cites W2041445627 @default.
• W2046457770 cites W2044926499 @default.
• W2046457770 cites W2056874799 @default.
• W2046457770 cites W2058357563 @default.
• W2046457770 cites W2060793395 @default.
• W2046457770 cites W2064582505 @default.
• W2046457770 cites W2066460470 @default.
• W2046457770 cites W2067523360 @default.
• W2046457770 cites W2069409557 @default.
• W2046457770 cites W2070030825 @default.
• W2046457770 cites W2076488710 @default.
• W2046457770 cites W2087505606 @default.
• W2046457770 cites W2088286541 @default.
• W2046457770 cites W2154208494 @default.
• W2046457770 cites W2155533824 @default.
• W2046457770 cites W2319180293 @default.
• W2046457770 cites W4229945324 @default.
• W2046457770 cites W4256017688 @default.
• W2046457770 doi "https://doi.org/10.1016/s0026-0495(96)90288-7" @default.
• W2046457770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8606641" @default.
• W2046457770 hasPublicationYear "1996" @default.
• W2046457770 type Work @default.
• W2046457770 sameAs 2046457770 @default.
• W2046457770 citedByCount "45" @default.
• W2046457770 countsByYear W20464577702012 @default.
• W2046457770 countsByYear W20464577702014 @default.
• W2046457770 countsByYear W20464577702015 @default.
• W2046457770 countsByYear W20464577702016 @default.
• W2046457770 countsByYear W20464577702017 @default.
• W2046457770 countsByYear W20464577702019 @default.
• W2046457770 countsByYear W20464577702021 @default.
• W2046457770 countsByYear W20464577702022 @default.
• W2046457770 crossrefType "journal-article" @default.
• W2046457770 hasAuthorship W2046457770A5007907892 @default.
• W2046457770 hasAuthorship W2046457770A5016794850 @default.
• W2046457770 hasAuthorship W2046457770A5038835910 @default.
• W2046457770 hasAuthorship W2046457770A5048030797 @default.
• W2046457770 hasAuthorship W2046457770A5056162271 @default.
• W2046457770 hasAuthorship W2046457770A5057537921 @default.
• W2046457770 hasAuthorship W2046457770A5085189039 @default.
• W2046457770 hasAuthorship W2046457770A5090420431 @default.
• W2046457770 hasConcept C126322002 @default.
• W2046457770 hasConcept C134018914 @default.
• W2046457770 hasConcept C185592680 @default.
• W2046457770 hasConcept C2777468819 @default.
• W2046457770 hasConcept C2780221984 @default.
• W2046457770 hasConcept C2781042741 @default.
• W2046457770 hasConcept C2984496839 @default.
• W2046457770 hasConcept C511355011 @default.
• W2046457770 hasConcept C515207424 @default.
• W2046457770 hasConcept C55493867 @default.
• W2046457770 hasConcept C71315377 @default.
• W2046457770 hasConcept C71924100 @default.
• W2046457770 hasConceptScore W2046457770C126322002 @default.
• W2046457770 hasConceptScore W2046457770C134018914 @default.
• W2046457770 hasConceptScore W2046457770C185592680 @default.
• W2046457770 hasConceptScore W2046457770C2777468819 @default.
• W2046457770 hasConceptScore W2046457770C2780221984 @default.
• W2046457770 hasConceptScore W2046457770C2781042741 @default.
• W2046457770 hasConceptScore W2046457770C2984496839 @default.
• W2046457770 hasConceptScore W2046457770C511355011 @default.
• W2046457770 hasConceptScore W2046457770C515207424 @default.
• W2046457770 hasConceptScore W2046457770C55493867 @default.
• W2046457770 hasConceptScore W2046457770C71315377 @default.
• W2046457770 hasConceptScore W2046457770C71924100 @default.
• W2046457770 hasIssue "3" @default.
• W2046457770 hasLocation W20464577701 @default.
• W2046457770 hasLocation W20464577702 @default.
• W2046457770 hasOpenAccess W2046457770 @default.
• W2046457770 hasPrimaryLocation W20464577701 @default.
• W2046457770 hasRelatedWork W1983507420 @default.
• W2046457770 hasRelatedWork W2062231047 @default.

• next