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- W2046457819 abstract "ATP activated the K+ channel responsible for outwardly rectifying currents via a P2Y purinoceptor linked to a pertussis toxin-insensitive G-protein in cultured rat spinal neurons. The evoked currents were inhibited by a selective protein kinase C inhibitor, GF109203X, whereas a phospholipase C inhibitor, neomycin had no effect. These indicate that the currents are regulated by phospholipase C-independent protein kinase C activation. In addition, ATP enhanced intracellular free Ca2+ concentration. The increase in intracellular free Ca2+ concentration was inhibited by a broad G-protein inhibitor, GDPβS, but not affected by neomycin or an inositol 1,4,5-triphosphate receptor antagonist, heparin, suggesting that the cytosolic Ca2+ mobilization is regulated by a mechanism independent of a phospholipase C-mediated phosphatidylinositol signaling. These results. thus, demonstrate that ATP has dual actions on the coupled K+ channel and cytosolic Ca2+ release." @default.
- W2046457819 created "2016-06-24" @default.
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- W2046457819 date "1996-04-01" @default.
- W2046457819 modified "2023-09-26" @default.
- W2046457819 title "ATP-regulated K+ channel and cytosolic Ca2+ mobilization in cultured rat spinal neurons" @default.
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- W2046457819 doi "https://doi.org/10.1016/0014-2999(96)00057-x" @default.
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