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• W2046487811 abstract "Background: In children, the incidence of off-label prescriptions in primary care varies between 10·5% and 22·7%, whilst the incidence of unlicensed prescriptions in primary care varies between 0·3% and 16·6%. This information has not been investigated in Malta.Objective: To identify therapeutic areas which warrant research in children in the community setting in Malta according to the proportion and nature of off-label and unlicensed medicinal use.Methods: Interim analysis involving the assessment of prescriptions for children in a prospective pharmaco-epidemiological study. Data regarding prescriptions in 37 private clinics and pharmacies attended by paediatricians and family doctors were collected for a cohort of 209 patients aged 0–14 years. The medicines were categorised as licensed, unlicensed or off-label. They were also classified into various categories such as patient age-group, data collection period, prescriber type and Anatomical Therapeutic Chemical classification system.Results: 113 of 209 (54·1%) medicinal products were used in an off-label and unlicensed manner, the highest number being in the 2–11-years age range (76/209). The majority of drugs were for the respiratory system. The proportion off-label drug prescribing because of age decreased progressively with increasing age whilst the proportion off-label prescribing because of dose increased with age.Conclusion: The main cause of off-label prescribing appears to be a failure to adhere to licensed dose recommendations and a lack of agreement between the existing literature and drug licences." @default.
• W2046487811 created "2016-06-24" @default.
• W2046487811 creator A5022557761 @default.
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• W2046487811 date "2013-12-06" @default.
• W2046487811 modified "2023-10-18" @default.
• W2046487811 title "Off-label and unlicensed paediatric prescribing in a community setting: a prospective longitudinal cohort study in Malta" @default.
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• W2046487811 doi "https://doi.org/10.1179/204690513x13656734979929" @default.
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