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- W2046493399 abstract "We have shown previously that whereas acute exposure of cultured murine peritoneal macrophages inhibits phagocytosis, chronic exposure results in a putative tolerant/dependent state. We now report similar observations using human cultured monocyte-derived macrophages (hMDM) from a control population and from methadone patients. With hMDM, acute exposure to morphine and methadone inhibited phagocytosis in a dose-dependent manner. In contrast, chronic exposure resulted in eventual normalization of phagocytosis, indicating that a putative tolerant state to the opiates had developed. When opiates were withdrawn from chronically-exposed, tolerized hMDM, phagocytosis was once again depressed. The duration of withdrawal-induced depression lasted several hours, which is much longer than evidenced previously with murine macrophages. These data identify well with various in vivo studies on immune effects of opiate withdrawal; and, in so-doing, supplement ongoing speculation that opiate withdrawal is likely to have serious impact on host defenses of street heroin addicts." @default.
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- W2046493399 date "2008-05-30" @default.
- W2046493399 modified "2023-10-13" @default.
- W2046493399 title "Chronic exposure of human macrophages in vitro to morphine and methadone induces a putative tolerant/dependent state" @default.
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- W2046493399 doi "https://doi.org/10.1016/j.jneuroim.2008.03.004" @default.
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