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- W2046493497 abstract "Glial cell line neurotrophic factor(GDNF) is a potent survival factor for several types of neurons. GDNF binds with high affinity to the GDNF-family receptor α-1 (GFRα-1) which is expressed in different brain areas. In the present study, by using anatomical techniques, we document the phenotypic diversity among GFRα-1 expressing neurons in the CNS. GFRα-1 expression was found in GABA (γ-aminobutyric acid)-containing neurons distributed in the cortex, reticular thalamic nucleus and septum. While high expression of GFRα-1 was often observed in cholinergic motoneurons in the spinal cord, very few septal cholinergic neurons were found to express GFRα-1. GFRα-1 transcripts were also detected in catecholaminergic neurons in the periventricular hypothalamic nucleus, dorsal raphe nucleus and locus ceruleus. Within the raphe nucleus, GFRα-1 expression was prominent in many serotonergic neurons and in few neurons containing the enzyme nitric oxide synthase. As GFRα-1 is activated by GDNF and GDNF-related neurotrophic factors, the widespread distribution of GFRα-1 in neurons with different phenotypes indicates that the neuronal activity of these neurons is likely to be affected by GDNF and GDNF-related neurotrophic factors. This would result in the regulation of diverse neuronal pathways in the adult brain. Published by Elsevier Science Ltd on behalf of IBRO." @default.
- W2046493497 created "2016-06-24" @default.
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- W2046493497 date "2003-01-01" @default.
- W2046493497 modified "2023-10-18" @default.
- W2046493497 title "Glial cell line neurotrophic factor-family receptor α-1 is present in central neurons with distinct phenotypes" @default.
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- W2046493497 doi "https://doi.org/10.1016/s0306-4522(02)00559-6" @default.
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