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• W2046496684 abstract "HIV-seropositive opioid-dependent patients maintained on an opiate-agonist who continue to use cocaine and to engage in other high-risk behaviors may benefit from enhanced treatment services; however, there is currently little data to guide the formulation of such services. We report on a preliminary study in which six HIV-seropositive opioid- and cocaine-dependent patients were provided a 12-week comprehensive pharmacologic/psychosocial treatment program developed specifically to meet the treatment needs of HIV-seropositive drug users. This program was comprised of buprenorphine (12 mg/day), bupropion (150 mg/day), and twice weekly manual-guided group therapy. Results showed significant decreases in intravenous cocaine use, cocaine craving, and symptoms of depression. A post-hoc comparison to outcomes of eight HIV-seropositive patients receiving standard methadone-maintenance found no improvements for patients receiving standard care. Controlled investigation of enhanced drug treatment programs for HIV-seropositive patients may be warranted." @default.
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• W2046496684 date "1998-05-01" @default.
• W2046496684 modified "2023-10-18" @default.
• W2046496684 title "A Comprehensive Pharmacologic-Psychosocial Treatment Program for HIV-Seropositive Cocaine- and Opioid-Dependent Patients" @default.
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• W2046496684 doi "https://doi.org/10.1016/s0740-5472(97)00226-2" @default.
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