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• W2046502802 abstract "Summary Background and objective There are currently no sensitive and specific assays for activin B that could be utilized to study human biological fluids. The aim of this project was to develop and validate a ‘total’ activin B ELISA for use with human biological fluids and establish concentrations of activin B in the circulation and fluids from the reproductive organs. Design The new ELISA was validated and then used to measure activin B levels in the circulation of healthy participants, IVF patients, pregnant women and in ovarian follicular fluid and seminal plasma. Patients and measurements Healthy adult subjects ( n = 143), subjects from an IVF clinic ( n = 27) and pregnancy groups ( n = 29) were sampled. Results The sensitivity of the assay was 0·019 ng/ml. Validation of the activin B ELISA showed good recovery (90·7 ± 9·8%) and linearity in biological fluid and cell culture media and low cross‐reactivity with related analytes (inhibin B = 0·077% and activin A = 0·0034%). There was a negative correlation between activin B concentration ( r = −0·281, P < 0·011) and females with increasing age. Patients attending IVF clinics had significantly lower levels of activin B compared with gender‐matched control subjects. Ovarian follicular fluid and seminal plasma had 50–80 fold higher levels of activin B (mean = 5·35 and 3·66 ng/ml respectively) than sera (mean = 0·071 ng/ml). Conclusions This fully validated ELISA for activin B offers a tremendous utility for measuring this protein in a variety of normal physiological processes and in various clinical pathologies." @default.
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• W2046502802 date "2009-11-09" @default.
• W2046502802 modified "2023-10-15" @default.
• W2046502802 title "A new ‘total’ activin B enzyme-linked immunosorbent assay (ELISA): development and validation for human samples" @default.
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• W2046502802 doi "https://doi.org/10.1111/j.1365-2265.2009.03567.x" @default.
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