Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046504612> ?p ?o ?g. }
- W2046504612 endingPage "2035" @default.
- W2046504612 startingPage "2025" @default.
- W2046504612 abstract "Therapy of hepatitis C virus (HCV) infection may prevent progression to cirrhosis, hepatocellular carcinoma and end-stage liver disease. The cornerstone of treatment has long been standard IFN-α, the use of which was associated with a sustained biochemical and viral response in only a small proportion of patients. More recently, the success of interferon-based regimens has substantially improved due to the combination with the guanosine analogue ribavirin and to the advent of pegylated interferon formulations. However, even the most up-to-date regimens fail to cure the infection in many cases and are limited by side effects and high costs. A better understanding of the HCV genomic organisation, the elucidation of the three-dimensional structures of virally encoded enzymes and the recent development of a HCV-replicon system in human hepatoma (Huh-7) cells have led to significant advances in the development of new antiviral compounds, many of which are under evaluation in clinical trials. The aim of this review is to trace a brief overview of the progress made by interferon-based treatments for hepatitis C since their introduction in the early 1990s, and to highlight the results of recent clinical studies concerning new and emerging drugs." @default.
- W2046504612 created "2016-06-24" @default.
- W2046504612 creator A5036666985 @default.
- W2046504612 creator A5064956279 @default.
- W2046504612 creator A5072500126 @default.
- W2046504612 date "2006-10-01" @default.
- W2046504612 modified "2023-09-26" @default.
- W2046504612 title "Antiviral treatment of hepatitis C" @default.
- W2046504612 cites W1535549793 @default.
- W2046504612 cites W1934976864 @default.
- W2046504612 cites W1964180362 @default.
- W2046504612 cites W1966049263 @default.
- W2046504612 cites W1968950430 @default.
- W2046504612 cites W1969178220 @default.
- W2046504612 cites W1969654131 @default.
- W2046504612 cites W1969898114 @default.
- W2046504612 cites W1970053808 @default.
- W2046504612 cites W1970502859 @default.
- W2046504612 cites W1971545043 @default.
- W2046504612 cites W1972121563 @default.
- W2046504612 cites W1972208581 @default.
- W2046504612 cites W1973376188 @default.
- W2046504612 cites W1975620628 @default.
- W2046504612 cites W1976672969 @default.
- W2046504612 cites W1978339383 @default.
- W2046504612 cites W1980556463 @default.
- W2046504612 cites W1985882441 @default.
- W2046504612 cites W1992778012 @default.
- W2046504612 cites W1993484328 @default.
- W2046504612 cites W1996434966 @default.
- W2046504612 cites W2010415958 @default.
- W2046504612 cites W2015533723 @default.
- W2046504612 cites W2015828492 @default.
- W2046504612 cites W2021922468 @default.
- W2046504612 cites W2027545702 @default.
- W2046504612 cites W2028784076 @default.
- W2046504612 cites W2029944598 @default.
- W2046504612 cites W2033142105 @default.
- W2046504612 cites W2037693997 @default.
- W2046504612 cites W2039937486 @default.
- W2046504612 cites W2048187419 @default.
- W2046504612 cites W2052402745 @default.
- W2046504612 cites W2055828992 @default.
- W2046504612 cites W2057746441 @default.
- W2046504612 cites W2058720438 @default.
- W2046504612 cites W2059638323 @default.
- W2046504612 cites W2062720290 @default.
- W2046504612 cites W2076024060 @default.
- W2046504612 cites W2078269829 @default.
- W2046504612 cites W2078514030 @default.
- W2046504612 cites W2084880276 @default.
- W2046504612 cites W2091425424 @default.
- W2046504612 cites W2091937293 @default.
- W2046504612 cites W2099955730 @default.
- W2046504612 cites W2100227035 @default.
- W2046504612 cites W2100844926 @default.
- W2046504612 cites W2105662333 @default.
- W2046504612 cites W2112876622 @default.
- W2046504612 cites W2121595515 @default.
- W2046504612 cites W2124850951 @default.
- W2046504612 cites W2127685726 @default.
- W2046504612 cites W2139169187 @default.
- W2046504612 cites W2139677692 @default.
- W2046504612 cites W2142684817 @default.
- W2046504612 cites W2144518798 @default.
- W2046504612 cites W2147927464 @default.
- W2046504612 cites W2151898297 @default.
- W2046504612 cites W2155798686 @default.
- W2046504612 cites W2156574153 @default.
- W2046504612 cites W2157857312 @default.
- W2046504612 cites W2165715544 @default.
- W2046504612 cites W2168912424 @default.
- W2046504612 cites W2169406601 @default.
- W2046504612 cites W2314619766 @default.
- W2046504612 cites W2317554121 @default.
- W2046504612 cites W2332630894 @default.
- W2046504612 cites W2341616068 @default.
- W2046504612 cites W2419067839 @default.
- W2046504612 cites W2792087431 @default.
- W2046504612 cites W4243900919 @default.
- W2046504612 cites W4244312606 @default.
- W2046504612 cites W4255067440 @default.
- W2046504612 doi "https://doi.org/10.1517/14656566.7.15.2025" @default.
- W2046504612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17020430" @default.
- W2046504612 hasPublicationYear "2006" @default.
- W2046504612 type Work @default.
- W2046504612 sameAs 2046504612 @default.
- W2046504612 citedByCount "9" @default.
- W2046504612 countsByYear W20465046122013 @default.
- W2046504612 crossrefType "journal-article" @default.
- W2046504612 hasAuthorship W2046504612A5036666985 @default.
- W2046504612 hasAuthorship W2046504612A5064956279 @default.
- W2046504612 hasAuthorship W2046504612A5072500126 @default.
- W2046504612 hasConcept C126322002 @default.
- W2046504612 hasConcept C159047783 @default.
- W2046504612 hasConcept C203014093 @default.
- W2046504612 hasConcept C2522874641 @default.
- W2046504612 hasConcept C2776178377 @default.