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• W2046536979 abstract "Heterotrimeric G proteins are key transducers for signal transfer from outside of the cell. In addition to their regulation by the superfamily of G protein-coupled receptors, many if not all of the subtypes of heterotrimeric G proteins are also regulated by additional accessory proteins that influence guanine nucleotide binding and/or hydrolysis or subunit interactions. Activators of G protein signaling (AGS1-3) refer to a functionally defined group of proteins that activate G protein-signaling systems in the absence of a classical G protein-coupled receptor. AGS and related proteins provide unexpected insights into the regulation of the G protein activation/deactivation cycle and the functional roles of G proteins. These proteins likely play important roles in the generation of signaling complexes, the positioning of signaling proteins within the cell, and in biological roles of G proteins unrelated to a cell surface receptor. As such, these proteins and the concepts advanced with their discovery provide unexpected avenues for therapeutics and understanding disease mechanisms." @default.
• W2046536979 created "2016-06-24" @default.
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• W2046536979 date "2003-05-01" @default.
• W2046536979 modified "2023-09-23" @default.
• W2046536979 title "Accessory Proteins for G Protein-Signaling Systems: Activators of G Protein Signaling and Other Nonreceptor Proteins Influencing the Activation State of G Proteins" @default.
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• W2046536979 doi "https://doi.org/10.1080/10606820308240" @default.
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