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- W2046548932 abstract "In the immunocompromised patient, the pulmonary nodule remains a diagnostic and therapeutic challenge. We studied the incidence, cause, diagnosis, and therapy of pulmonary nodules after lung transplantation (LTx). Eight out of 64 patients (12.5%) developed pulmonary nodules after a median follow-up of 5.8 months (range, 1 to 10 months). The median age was 30.5 years (range, 21 to 62 years). Solitary pulmonary nodules (n=2) disappeared spontaneously within 3 weeks and were suspected to be of infectious origin. The cause of multiple nodules (n=6) was posttransplant lymphoproliferative disorder (PTLD [n=3]), aspergillosis (n=2), and abscesses caused by Pseudomonas aeruginosa and Staphylococcus aureus (n=1). After an initial chest radiograph, CT with fine-needle biopsy was the most valuable diagnostic tool. In six patients, nodules resolved within 10 weeks (median, 8 weeks). Two patients, however, died of sepsis (P aeruginosa and S aureus and Aspergillus, respectively). The differential diagnosis of pulmonary nodules after LTx primarily comprises PTLD and infection (bacterial or fungal). To improve the outcome, early, aggressive treatment is mandatory; therefore, serial CT scans are strongly recommended to be part of the diagnostic armamentarium in LTx recipients. In the immunocompromised patient, the pulmonary nodule remains a diagnostic and therapeutic challenge. We studied the incidence, cause, diagnosis, and therapy of pulmonary nodules after lung transplantation (LTx). Eight out of 64 patients (12.5%) developed pulmonary nodules after a median follow-up of 5.8 months (range, 1 to 10 months). The median age was 30.5 years (range, 21 to 62 years). Solitary pulmonary nodules (n=2) disappeared spontaneously within 3 weeks and were suspected to be of infectious origin. The cause of multiple nodules (n=6) was posttransplant lymphoproliferative disorder (PTLD [n=3]), aspergillosis (n=2), and abscesses caused by Pseudomonas aeruginosa and Staphylococcus aureus (n=1). After an initial chest radiograph, CT with fine-needle biopsy was the most valuable diagnostic tool. In six patients, nodules resolved within 10 weeks (median, 8 weeks). Two patients, however, died of sepsis (P aeruginosa and S aureus and Aspergillus, respectively). The differential diagnosis of pulmonary nodules after LTx primarily comprises PTLD and infection (bacterial or fungal). To improve the outcome, early, aggressive treatment is mandatory; therefore, serial CT scans are strongly recommended to be part of the diagnostic armamentarium in LTx recipients." @default.
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- W2046548932 date "1995-05-01" @default.
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- W2046548932 title "The Pulmonary Nodule After Lung Transplantation" @default.
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- W2046548932 doi "https://doi.org/10.1378/chest.107.5.1317" @default.
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