Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046553655> ?p ?o ?g. }
- W2046553655 endingPage "2465" @default.
- W2046553655 startingPage "2460" @default.
- W2046553655 abstract "The binding of heterotrimeric lymphotoxin, LT alpha1 beta2, to the LTbeta receptor (LTbeta R), a member of the tumor necrosis factor receptor (TNFR) superfamily, induces nuclear factor kappaB (NF-kappaB) activation and cell death in HT29 adenocarcinoma cells. We now show that treatment with LT alpha1 beta2 or agonistic LTbeta R antibodies causes rapid recruitment of TNFR-associated factor 3 (TRAF3) to the LTbeta R cytoplasmic domain. Further, stable overexpression of a TRAF3 mutant that lacks the RING and zinc finger domains inhibits LTbeta R-mediated cell death. The inhibition is specific for LTbeta R cell death signaling, since NF-kappaB activation by LT alpha1 beta2 and Fas-mediated apoptosis are not inhibited in the same cells. The mutant and endogenous TRAF3s are both recruited at equimolar amounts to the LTbeta R, suggesting that the mutant disrupts the function of the signaling complex. These results implicate TRAF3 as a critical component of the LTbeta R death signaling complex and indicate that at least two independent signaling pathways are initiated by LTbeta R ligation." @default.
- W2046553655 created "2016-06-24" @default.
- W2046553655 creator A5017391924 @default.
- W2046553655 creator A5054652279 @default.
- W2046553655 creator A5059438505 @default.
- W2046553655 creator A5060336842 @default.
- W2046553655 creator A5069383224 @default.
- W2046553655 creator A5073201377 @default.
- W2046553655 creator A5083595442 @default.
- W2046553655 creator A5089155935 @default.
- W2046553655 date "1997-03-18" @default.
- W2046553655 modified "2023-10-16" @default.
- W2046553655 title "Lymphotoxin-β receptor signaling complex: Role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor κB" @default.
- W2046553655 cites W146089551 @default.
- W2046553655 cites W1487048054 @default.
- W2046553655 cites W1489824092 @default.
- W2046553655 cites W1492606093 @default.
- W2046553655 cites W1509151953 @default.
- W2046553655 cites W1513658036 @default.
- W2046553655 cites W1513954632 @default.
- W2046553655 cites W1577393853 @default.
- W2046553655 cites W1580762659 @default.
- W2046553655 cites W1585074435 @default.
- W2046553655 cites W1705862960 @default.
- W2046553655 cites W1888783223 @default.
- W2046553655 cites W1963761369 @default.
- W2046553655 cites W1968328677 @default.
- W2046553655 cites W1971514924 @default.
- W2046553655 cites W1973680986 @default.
- W2046553655 cites W1982554152 @default.
- W2046553655 cites W1983668987 @default.
- W2046553655 cites W1986308149 @default.
- W2046553655 cites W1989997867 @default.
- W2046553655 cites W1997681070 @default.
- W2046553655 cites W2001718186 @default.
- W2046553655 cites W2002154440 @default.
- W2046553655 cites W2002507218 @default.
- W2046553655 cites W2005484362 @default.
- W2046553655 cites W2006281076 @default.
- W2046553655 cites W2013052118 @default.
- W2046553655 cites W2020680466 @default.
- W2046553655 cites W2023359747 @default.
- W2046553655 cites W2025026731 @default.
- W2046553655 cites W2027998343 @default.
- W2046553655 cites W2029501678 @default.
- W2046553655 cites W2029875651 @default.
- W2046553655 cites W2030829559 @default.
- W2046553655 cites W2032417513 @default.
- W2046553655 cites W2032514624 @default.
- W2046553655 cites W2036528355 @default.
- W2046553655 cites W2039428188 @default.
- W2046553655 cites W2041354260 @default.
- W2046553655 cites W2041466047 @default.
- W2046553655 cites W2053301460 @default.
- W2046553655 cites W2073578202 @default.
- W2046553655 cites W2079199354 @default.
- W2046553655 cites W2082575834 @default.
- W2046553655 cites W2086255604 @default.
- W2046553655 cites W2089651572 @default.
- W2046553655 cites W2090125712 @default.
- W2046553655 cites W2127520526 @default.
- W2046553655 cites W2129345746 @default.
- W2046553655 cites W2133074755 @default.
- W2046553655 cites W2134636854 @default.
- W2046553655 cites W2135627750 @default.
- W2046553655 cites W2139319526 @default.
- W2046553655 cites W2141409173 @default.
- W2046553655 cites W2146101256 @default.
- W2046553655 cites W2152445095 @default.
- W2046553655 cites W2157265156 @default.
- W2046553655 cites W2157825598 @default.
- W2046553655 cites W2161680868 @default.
- W2046553655 cites W2165042359 @default.
- W2046553655 cites W2167259834 @default.
- W2046553655 cites W2442722275 @default.
- W2046553655 doi "https://doi.org/10.1073/pnas.94.6.2460" @default.
- W2046553655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/20110" @default.
- W2046553655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9122217" @default.
- W2046553655 hasPublicationYear "1997" @default.
- W2046553655 type Work @default.
- W2046553655 sameAs 2046553655 @default.
- W2046553655 citedByCount "163" @default.
- W2046553655 countsByYear W20465536552013 @default.
- W2046553655 countsByYear W20465536552014 @default.
- W2046553655 countsByYear W20465536552015 @default.
- W2046553655 countsByYear W20465536552016 @default.
- W2046553655 countsByYear W20465536552017 @default.
- W2046553655 countsByYear W20465536552018 @default.
- W2046553655 countsByYear W20465536552019 @default.
- W2046553655 countsByYear W20465536552020 @default.
- W2046553655 countsByYear W20465536552021 @default.
- W2046553655 countsByYear W20465536552022 @default.
- W2046553655 crossrefType "journal-article" @default.
- W2046553655 hasAuthorship W2046553655A5017391924 @default.
- W2046553655 hasAuthorship W2046553655A5054652279 @default.
- W2046553655 hasAuthorship W2046553655A5059438505 @default.
- W2046553655 hasAuthorship W2046553655A5060336842 @default.
- W2046553655 hasAuthorship W2046553655A5069383224 @default.