Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046556545> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2046556545 endingPage "73" @default.
- W2046556545 startingPage "66" @default.
- W2046556545 abstract "Differential display PCR was used to identify genes regulated by mood stabilizer lithium in rat cerebral cortex. A differentially displayed lithium regulated gene fragment was isolated in rat cerebral cortex after chronic treatment with lithium (1.69 g/kg, p.o. ) for three weeks. A 1216-nucleotide cDNA for a novel lithium regulated gene (NLRG) was isolated from a rat brain cDNA library with RACE (rapid amplification of 5' cDNA end) PCR using a prime from the differentially displayed NLRG gene fragment. The deduced protein sequence was 321 amino acids long, and shows a significant homology with yeast nitrogen permease regulator 2 (NPR2). NLRG expression induced by lithium was confirmed by Northern and slot blot analysis in rat cerebral cortex and neuroblastomaxglioma NG108-15 cells, respectively. In situ hybridization revealed that chronic treatment with lithium increased NLRG gene expression in frontal cortex and hippocampus, but not in striatum, hypothalamus and thalamus regions of rat brain. These results suggest a novel target for lithium which may be relevant to its mechanism of action." @default.
- W2046556545 created "2016-06-24" @default.
- W2046556545 creator A5024208397 @default.
- W2046556545 creator A5036837044 @default.
- W2046556545 creator A5064531609 @default.
- W2046556545 date "1999-06-01" @default.
- W2046556545 modified "2023-10-07" @default.
- W2046556545 title "Identification of a novel lithium regulated gene in rat brain" @default.
- W2046556545 cites W1975304761 @default.
- W2046556545 cites W1978368163 @default.
- W2046556545 cites W1983610668 @default.
- W2046556545 cites W1984935769 @default.
- W2046556545 cites W1987059053 @default.
- W2046556545 cites W1992238265 @default.
- W2046556545 cites W1995522877 @default.
- W2046556545 cites W1998252274 @default.
- W2046556545 cites W1998701465 @default.
- W2046556545 cites W2001641196 @default.
- W2046556545 cites W2008137448 @default.
- W2046556545 cites W2010152065 @default.
- W2046556545 cites W2014669590 @default.
- W2046556545 cites W2015779369 @default.
- W2046556545 cites W2029881647 @default.
- W2046556545 cites W2034988662 @default.
- W2046556545 cites W2035008373 @default.
- W2046556545 cites W2035185470 @default.
- W2046556545 cites W2036111134 @default.
- W2046556545 cites W2044239520 @default.
- W2046556545 cites W2053196200 @default.
- W2046556545 cites W2055043387 @default.
- W2046556545 cites W2064978671 @default.
- W2046556545 cites W2067210255 @default.
- W2046556545 cites W2074933601 @default.
- W2046556545 cites W2083942007 @default.
- W2046556545 cites W2088749504 @default.
- W2046556545 cites W2089686383 @default.
- W2046556545 cites W2091287612 @default.
- W2046556545 cites W2106918877 @default.
- W2046556545 cites W2138270253 @default.
- W2046556545 cites W2140583479 @default.
- W2046556545 cites W2224929038 @default.
- W2046556545 doi "https://doi.org/10.1016/s0169-328x(99)00128-x" @default.
- W2046556545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10381544" @default.
- W2046556545 hasPublicationYear "1999" @default.
- W2046556545 type Work @default.
- W2046556545 sameAs 2046556545 @default.
- W2046556545 citedByCount "18" @default.
- W2046556545 countsByYear W20465565452015 @default.
- W2046556545 countsByYear W20465565452018 @default.
- W2046556545 crossrefType "journal-article" @default.
- W2046556545 hasAuthorship W2046556545A5024208397 @default.
- W2046556545 hasAuthorship W2046556545A5036837044 @default.
- W2046556545 hasAuthorship W2046556545A5064531609 @default.
- W2046556545 hasConcept C104317684 @default.
- W2046556545 hasConcept C134018914 @default.
- W2046556545 hasConcept C150194340 @default.
- W2046556545 hasConcept C153911025 @default.
- W2046556545 hasConcept C177707886 @default.
- W2046556545 hasConcept C187882448 @default.
- W2046556545 hasConcept C189482833 @default.
- W2046556545 hasConcept C2781041448 @default.
- W2046556545 hasConcept C55493867 @default.
- W2046556545 hasConcept C81439078 @default.
- W2046556545 hasConcept C86803240 @default.
- W2046556545 hasConceptScore W2046556545C104317684 @default.
- W2046556545 hasConceptScore W2046556545C134018914 @default.
- W2046556545 hasConceptScore W2046556545C150194340 @default.
- W2046556545 hasConceptScore W2046556545C153911025 @default.
- W2046556545 hasConceptScore W2046556545C177707886 @default.
- W2046556545 hasConceptScore W2046556545C187882448 @default.
- W2046556545 hasConceptScore W2046556545C189482833 @default.
- W2046556545 hasConceptScore W2046556545C2781041448 @default.
- W2046556545 hasConceptScore W2046556545C55493867 @default.
- W2046556545 hasConceptScore W2046556545C81439078 @default.
- W2046556545 hasConceptScore W2046556545C86803240 @default.
- W2046556545 hasIssue "1" @default.
- W2046556545 hasLocation W20465565451 @default.
- W2046556545 hasLocation W20465565452 @default.
- W2046556545 hasOpenAccess W2046556545 @default.
- W2046556545 hasPrimaryLocation W20465565451 @default.
- W2046556545 hasRelatedWork W2032180350 @default.
- W2046556545 hasRelatedWork W2073165201 @default.
- W2046556545 hasRelatedWork W2352079703 @default.
- W2046556545 hasRelatedWork W2353741247 @default.
- W2046556545 hasRelatedWork W2353824990 @default.
- W2046556545 hasRelatedWork W2359830222 @default.
- W2046556545 hasRelatedWork W2368164920 @default.
- W2046556545 hasRelatedWork W2375797727 @default.
- W2046556545 hasRelatedWork W2378310469 @default.
- W2046556545 hasRelatedWork W303721980 @default.
- W2046556545 hasVolume "70" @default.
- W2046556545 isParatext "false" @default.
- W2046556545 isRetracted "false" @default.
- W2046556545 magId "2046556545" @default.
- W2046556545 workType "article" @default.