Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046556656> ?p ?o ?g. }
- W2046556656 endingPage "20" @default.
- W2046556656 startingPage "12" @default.
- W2046556656 abstract "Vertebrate lens development depends on a complex network of signaling molecules to coordinate cell proliferation, migration and differentiation. In this study, we have investigated the role of heparan sulfate in lens specific signaling by generating a conditional ablation of heparan sulfate modification genes, Ndst1 and Ndst2. In this mutant, N-sulfation of heparan sulfate was disrupted after the lens induction stage, resulting in reduced lens cell proliferation, increased cell death and defective lens fiber differentiation in later lens development. The loss of Ndst function also prevented the assembly of Fgf/Fgfr complexes on the lens cell surface and disrupted ERK signaling within the lens. We further demonstrated that Ndst mutation completely inhibited the FGF1 and Fgf3 overexpression phenotypes, but Kras reactivation was sufficient to reverse the Ndst deficient lens differentiation defect. The epistatic relationship between Ndst and FGF-Ras signaling demonstrates that FGF signaling is the predominant signaling pathway controlled by Ndst in lens development." @default.
- W2046556656 created "2016-06-24" @default.
- W2046556656 creator A5006651636 @default.
- W2046556656 creator A5041107408 @default.
- W2046556656 creator A5059881668 @default.
- W2046556656 creator A5060816611 @default.
- W2046556656 creator A5067301817 @default.
- W2046556656 creator A5090315899 @default.
- W2046556656 date "2011-07-01" @default.
- W2046556656 modified "2023-10-10" @default.
- W2046556656 title "Genetic epistasis between heparan sulfate and FGF–Ras signaling controls lens development" @default.
- W2046556656 cites W1519269060 @default.
- W2046556656 cites W1566845359 @default.
- W2046556656 cites W1789601839 @default.
- W2046556656 cites W1917414630 @default.
- W2046556656 cites W1977495197 @default.
- W2046556656 cites W1986456038 @default.
- W2046556656 cites W1987348253 @default.
- W2046556656 cites W1997277166 @default.
- W2046556656 cites W2000952815 @default.
- W2046556656 cites W2013965967 @default.
- W2046556656 cites W2019800582 @default.
- W2046556656 cites W2037076508 @default.
- W2046556656 cites W2043407580 @default.
- W2046556656 cites W2043597725 @default.
- W2046556656 cites W2044601472 @default.
- W2046556656 cites W2050389860 @default.
- W2046556656 cites W2059609447 @default.
- W2046556656 cites W2059840788 @default.
- W2046556656 cites W2062519756 @default.
- W2046556656 cites W2065823804 @default.
- W2046556656 cites W2070318120 @default.
- W2046556656 cites W2072303535 @default.
- W2046556656 cites W2080425802 @default.
- W2046556656 cites W2081820386 @default.
- W2046556656 cites W2082541916 @default.
- W2046556656 cites W2096754487 @default.
- W2046556656 cites W2100177764 @default.
- W2046556656 cites W2110599075 @default.
- W2046556656 cites W2124518520 @default.
- W2046556656 cites W2132493358 @default.
- W2046556656 cites W2134321528 @default.
- W2046556656 cites W2141843510 @default.
- W2046556656 cites W2153236138 @default.
- W2046556656 cites W2156014566 @default.
- W2046556656 cites W2166677271 @default.
- W2046556656 cites W2181846459 @default.
- W2046556656 cites W2183350970 @default.
- W2046556656 cites W2211576543 @default.
- W2046556656 cites W2337257182 @default.
- W2046556656 cites W2404947585 @default.
- W2046556656 doi "https://doi.org/10.1016/j.ydbio.2011.04.007" @default.
- W2046556656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3104109" @default.
- W2046556656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21536023" @default.
- W2046556656 hasPublicationYear "2011" @default.
- W2046556656 type Work @default.
- W2046556656 sameAs 2046556656 @default.
- W2046556656 citedByCount "35" @default.
- W2046556656 countsByYear W20465566562012 @default.
- W2046556656 countsByYear W20465566562013 @default.
- W2046556656 countsByYear W20465566562014 @default.
- W2046556656 countsByYear W20465566562015 @default.
- W2046556656 countsByYear W20465566562016 @default.
- W2046556656 countsByYear W20465566562017 @default.
- W2046556656 countsByYear W20465566562018 @default.
- W2046556656 countsByYear W20465566562019 @default.
- W2046556656 countsByYear W20465566562020 @default.
- W2046556656 countsByYear W20465566562022 @default.
- W2046556656 countsByYear W20465566562023 @default.
- W2046556656 crossrefType "journal-article" @default.
- W2046556656 hasAuthorship W2046556656A5006651636 @default.
- W2046556656 hasAuthorship W2046556656A5041107408 @default.
- W2046556656 hasAuthorship W2046556656A5059881668 @default.
- W2046556656 hasAuthorship W2046556656A5060816611 @default.
- W2046556656 hasAuthorship W2046556656A5067301817 @default.
- W2046556656 hasAuthorship W2046556656A5090315899 @default.
- W2046556656 hasBestOaLocation W20465566561 @default.
- W2046556656 hasConcept C151730666 @default.
- W2046556656 hasConcept C153074725 @default.
- W2046556656 hasConcept C15336307 @default.
- W2046556656 hasConcept C170493617 @default.
- W2046556656 hasConcept C2778041096 @default.
- W2046556656 hasConcept C54355233 @default.
- W2046556656 hasConcept C55493867 @default.
- W2046556656 hasConcept C62478195 @default.
- W2046556656 hasConcept C74373430 @default.
- W2046556656 hasConcept C86803240 @default.
- W2046556656 hasConcept C95444343 @default.
- W2046556656 hasConceptScore W2046556656C151730666 @default.
- W2046556656 hasConceptScore W2046556656C153074725 @default.
- W2046556656 hasConceptScore W2046556656C15336307 @default.
- W2046556656 hasConceptScore W2046556656C170493617 @default.
- W2046556656 hasConceptScore W2046556656C2778041096 @default.
- W2046556656 hasConceptScore W2046556656C54355233 @default.
- W2046556656 hasConceptScore W2046556656C55493867 @default.
- W2046556656 hasConceptScore W2046556656C62478195 @default.
- W2046556656 hasConceptScore W2046556656C74373430 @default.
- W2046556656 hasConceptScore W2046556656C86803240 @default.