Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046557593> ?p ?o ?g. }
- W2046557593 endingPage "913" @default.
- W2046557593 startingPage "909" @default.
- W2046557593 abstract "Abstract Gains and losses of chromosomes 1, 3, 6 and 8 are nonrandom chromosomal aberrations in uveal melanoma. Monosomy 3 is the most frequent abnormality and is associated with poor prognosis. To identify regions of allelic loss on the short arm of chromosome 1 and to investigate if these alterations contribute to uveal melanoma progression, we performed microsatellite analysis of 10 loci in 70 uveal melanomas. A total of 51 tumors were obtained from patients with clinical follow‐up data, 19 tumors were from recent patients without follow‐up. Loss of heterozygosity (LOH) of at least 1 marker was more frequent in tumors with monosomy 3 (40%) than in tumors with disomy 3 (10%). In particular, loss of the entire short arm of chromosome 1 was only observed in tumors with monosomy 3 ( p = 0.0001). By comparing the extent of 1p LOH in all tumors with monosomy 3, we were able to define a smallest region of overlap (SRO) of approximately 55 Mb, which is flanked by markers D1S507 and D1S198 . On the basis of our data and published cytogenetic data, we propose that 1p31 harbors genes involved in the progression of uveal melanoma with monosomy 3. © 2005 Wiley‐Liss, Inc." @default.
- W2046557593 created "2016-06-24" @default.
- W2046557593 creator A5007240349 @default.
- W2046557593 creator A5012441263 @default.
- W2046557593 creator A5050610275 @default.
- W2046557593 creator A5060093906 @default.
- W2046557593 creator A5063363339 @default.
- W2046557593 creator A5069955866 @default.
- W2046557593 creator A5080262061 @default.
- W2046557593 creator A5089186966 @default.
- W2046557593 date "2005-04-22" @default.
- W2046557593 modified "2023-10-10" @default.
- W2046557593 title "Loss of heterozygosity of 1p in uveal melanomas with monosomy 3" @default.
- W2046557593 cites W1591974336 @default.
- W2046557593 cites W1974715203 @default.
- W2046557593 cites W1975679429 @default.
- W2046557593 cites W1978731309 @default.
- W2046557593 cites W1981745249 @default.
- W2046557593 cites W1985219162 @default.
- W2046557593 cites W2008732999 @default.
- W2046557593 cites W2043968939 @default.
- W2046557593 cites W2050728254 @default.
- W2046557593 cites W2055835855 @default.
- W2046557593 cites W2076672578 @default.
- W2046557593 cites W2091841363 @default.
- W2046557593 cites W2107969863 @default.
- W2046557593 cites W2157070790 @default.
- W2046557593 cites W23145292 @default.
- W2046557593 cites W4242638449 @default.
- W2046557593 doi "https://doi.org/10.1002/ijc.21086" @default.
- W2046557593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15849744" @default.
- W2046557593 hasPublicationYear "2005" @default.
- W2046557593 type Work @default.
- W2046557593 sameAs 2046557593 @default.
- W2046557593 citedByCount "61" @default.
- W2046557593 countsByYear W20465575932012 @default.
- W2046557593 countsByYear W20465575932013 @default.
- W2046557593 countsByYear W20465575932014 @default.
- W2046557593 countsByYear W20465575932015 @default.
- W2046557593 countsByYear W20465575932016 @default.
- W2046557593 countsByYear W20465575932017 @default.
- W2046557593 countsByYear W20465575932018 @default.
- W2046557593 countsByYear W20465575932019 @default.
- W2046557593 countsByYear W20465575932020 @default.
- W2046557593 countsByYear W20465575932021 @default.
- W2046557593 countsByYear W20465575932022 @default.
- W2046557593 countsByYear W20465575932023 @default.
- W2046557593 crossrefType "journal-article" @default.
- W2046557593 hasAuthorship W2046557593A5007240349 @default.
- W2046557593 hasAuthorship W2046557593A5012441263 @default.
- W2046557593 hasAuthorship W2046557593A5050610275 @default.
- W2046557593 hasAuthorship W2046557593A5060093906 @default.
- W2046557593 hasAuthorship W2046557593A5063363339 @default.
- W2046557593 hasAuthorship W2046557593A5069955866 @default.
- W2046557593 hasAuthorship W2046557593A5080262061 @default.
- W2046557593 hasAuthorship W2046557593A5089186966 @default.
- W2046557593 hasBestOaLocation W20465575931 @default.
- W2046557593 hasConcept C104317684 @default.
- W2046557593 hasConcept C109748351 @default.
- W2046557593 hasConcept C142724271 @default.
- W2046557593 hasConcept C143589142 @default.
- W2046557593 hasConcept C174475383 @default.
- W2046557593 hasConcept C180754005 @default.
- W2046557593 hasConcept C2777658100 @default.
- W2046557593 hasConcept C2779142324 @default.
- W2046557593 hasConcept C2779672484 @default.
- W2046557593 hasConcept C30481170 @default.
- W2046557593 hasConcept C47924181 @default.
- W2046557593 hasConcept C502942594 @default.
- W2046557593 hasConcept C53226629 @default.
- W2046557593 hasConcept C54355233 @default.
- W2046557593 hasConcept C71924100 @default.
- W2046557593 hasConcept C86803240 @default.
- W2046557593 hasConceptScore W2046557593C104317684 @default.
- W2046557593 hasConceptScore W2046557593C109748351 @default.
- W2046557593 hasConceptScore W2046557593C142724271 @default.
- W2046557593 hasConceptScore W2046557593C143589142 @default.
- W2046557593 hasConceptScore W2046557593C174475383 @default.
- W2046557593 hasConceptScore W2046557593C180754005 @default.
- W2046557593 hasConceptScore W2046557593C2777658100 @default.
- W2046557593 hasConceptScore W2046557593C2779142324 @default.
- W2046557593 hasConceptScore W2046557593C2779672484 @default.
- W2046557593 hasConceptScore W2046557593C30481170 @default.
- W2046557593 hasConceptScore W2046557593C47924181 @default.
- W2046557593 hasConceptScore W2046557593C502942594 @default.
- W2046557593 hasConceptScore W2046557593C53226629 @default.
- W2046557593 hasConceptScore W2046557593C54355233 @default.
- W2046557593 hasConceptScore W2046557593C71924100 @default.
- W2046557593 hasConceptScore W2046557593C86803240 @default.
- W2046557593 hasIssue "6" @default.
- W2046557593 hasLocation W20465575931 @default.
- W2046557593 hasLocation W20465575932 @default.
- W2046557593 hasOpenAccess W2046557593 @default.
- W2046557593 hasPrimaryLocation W20465575931 @default.
- W2046557593 hasRelatedWork W1521892020 @default.
- W2046557593 hasRelatedWork W2046557593 @default.
- W2046557593 hasRelatedWork W2053208278 @default.
- W2046557593 hasRelatedWork W2070465958 @default.