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- W2046560912 abstract "To discover a highly selective M(3) antagonist, a combinatorial library was prepared. The library was designed to identify a novel structural class of M(3) antagonists by exploring the spatial arrangement of the pharmacophores in known M(3) antagonists. After the evaluation of 1000 library members, a potent M(3) antagonist, 14a (K(i) = 0.31 nM), with novel structural features was identified. Compound 14a showed high selectivity for M(3) receptors over the other muscarinic receptor subtypes (M(1)/M(3) = 380-fold, M(2)/M(3) = 98-fold, M(4)/M(3) = 45-fold, M(5)/M(3) = 120-fold)." @default.
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- W2046560912 date "2002-01-18" @default.
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- W2046560912 title "Cyclohexylmethylpiperidinyltriphenylpropioamide: A Selective Muscarinic M<sub>3</sub> Antagonist Discriminating against the Other Receptor Subtypes" @default.
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- W2046560912 doi "https://doi.org/10.1021/jm010480k" @default.
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