FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046580842> ?p ?o ?g. }

• W2046580842 endingPage "783" @default.
• W2046580842 startingPage "779" @default.
• W2046580842 abstract "Our study aimed at evaluating the presence of human papillomavirus (HPV) DNA in a series of 84 paraffin-embedded (PET) penile carcinomas. We have also investigated the presence of p53 mutations in these tumors by immunohistochemistry (IHC), single-stranded conformational polymorphism (SSCP) and DNA sequencing. Tissues were submitted to amplification of a 268 bp fragment from the beta-globin gene and a fragment of the E6 gene of HPV types 6, 11, 16 and 18. Twenty samples (18 fixed in Bouin's solution and 2 in buffered formalin) were found inadequate and were excluded from the analysis. In the remaining 64 tumors, HPV DNA was found in 26% of the samples. The prevalence of HPV in fresh samples of the same tumors was 56%. The most prevalent type was HPV 16 in both fresh samples and PET. Isotopic in situ hybridization was performed in all PET samples, but only 2 cases were positive, 1 for HPV 16 and 1 for HPV 18. Immunohistochemistry with anti-p53 pAb 1801 antibody showed a positive nuclear reaction over more than 5% of tumor cells in 26% of the cases. SSCP of exons 5-8 of the p53 gene was performed on 9 HPV-positive and 12 HPV-negative specimens. Abnormal mobility was found in 26% of the tumors, of which 2 were HPV-positive and 5 HPV-negative. Point mutations were detected in p53 exons 6 (1 case), 7 (1 case) and 8 (5 cases), showing that high-risk type HPVs and mutated p53 may coexist in these tumors. Our data indicate that a subset of penile carcinomas are etiologically related to HPV and that an overlapping subset may arise from mutational events in the p53 gene." @default.
• W2046580842 created "2016-06-24" @default.
• W2046580842 creator A5021037940 @default.
• W2046580842 creator A5021456151 @default.
• W2046580842 creator A5076252341 @default.
• W2046580842 creator A5078214986 @default.
• W2046580842 date "1998-06-10" @default.
• W2046580842 modified "2023-10-17" @default.
• W2046580842 title "Human papillomavirus DNA andp53 status in penile carcinomas" @default.
• W2046580842 cites W1971215274 @default.
• W2046580842 cites W1981905560 @default.
• W2046580842 cites W1996858885 @default.
• W2046580842 cites W1997521650 @default.
• W2046580842 cites W2000574140 @default.
• W2046580842 cites W2036798490 @default.
• W2046580842 cites W2040031103 @default.
• W2046580842 cites W2042316019 @default.
• W2046580842 cites W2044065888 @default.
• W2046580842 cites W2051226734 @default.
• W2046580842 cites W2055395033 @default.
• W2046580842 cites W2068598562 @default.
• W2046580842 cites W2078066154 @default.
• W2046580842 cites W2085234632 @default.
• W2046580842 cites W2102901342 @default.
• W2046580842 cites W2107768636 @default.
• W2046580842 cites W2109119355 @default.
• W2046580842 cites W2125685112 @default.
• W2046580842 cites W2140894046 @default.
• W2046580842 cites W2140992062 @default.
• W2046580842 cites W2325315443 @default.
• W2046580842 cites W2407851486 @default.
• W2046580842 doi "https://doi.org/10.1002/(sici)1097-0215(19980610)76:6<779::aid-ijc1>3.0.co;2-v" @default.
• W2046580842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9626339" @default.
• W2046580842 hasPublicationYear "1998" @default.
• W2046580842 type Work @default.
• W2046580842 sameAs 2046580842 @default.
• W2046580842 citedByCount "65" @default.
• W2046580842 countsByYear W20465808422012 @default.
• W2046580842 countsByYear W20465808422013 @default.
• W2046580842 countsByYear W20465808422014 @default.
• W2046580842 countsByYear W20465808422015 @default.
• W2046580842 countsByYear W20465808422016 @default.
• W2046580842 countsByYear W20465808422019 @default.
• W2046580842 countsByYear W20465808422020 @default.
• W2046580842 countsByYear W20465808422022 @default.
• W2046580842 crossrefType "journal-article" @default.
• W2046580842 hasAuthorship W2046580842A5021037940 @default.
• W2046580842 hasAuthorship W2046580842A5021456151 @default.
• W2046580842 hasAuthorship W2046580842A5076252341 @default.
• W2046580842 hasAuthorship W2046580842A5078214986 @default.
• W2046580842 hasBestOaLocation W20465808421 @default.
• W2046580842 hasConcept C104317684 @default.
• W2046580842 hasConcept C129219603 @default.
• W2046580842 hasConcept C142724271 @default.
• W2046580842 hasConcept C150194340 @default.
• W2046580842 hasConcept C153911025 @default.
• W2046580842 hasConcept C176944494 @default.
• W2046580842 hasConcept C204232928 @default.
• W2046580842 hasConcept C36823959 @default.
• W2046580842 hasConcept C49105822 @default.
• W2046580842 hasConcept C501734568 @default.
• W2046580842 hasConcept C54355233 @default.
• W2046580842 hasConcept C552990157 @default.
• W2046580842 hasConcept C71924100 @default.
• W2046580842 hasConcept C81439078 @default.
• W2046580842 hasConcept C86803240 @default.
• W2046580842 hasConceptScore W2046580842C104317684 @default.
• W2046580842 hasConceptScore W2046580842C129219603 @default.
• W2046580842 hasConceptScore W2046580842C142724271 @default.
• W2046580842 hasConceptScore W2046580842C150194340 @default.
• W2046580842 hasConceptScore W2046580842C153911025 @default.
• W2046580842 hasConceptScore W2046580842C176944494 @default.
• W2046580842 hasConceptScore W2046580842C204232928 @default.
• W2046580842 hasConceptScore W2046580842C36823959 @default.
• W2046580842 hasConceptScore W2046580842C49105822 @default.
• W2046580842 hasConceptScore W2046580842C501734568 @default.
• W2046580842 hasConceptScore W2046580842C54355233 @default.
• W2046580842 hasConceptScore W2046580842C552990157 @default.
• W2046580842 hasConceptScore W2046580842C71924100 @default.
• W2046580842 hasConceptScore W2046580842C81439078 @default.
• W2046580842 hasConceptScore W2046580842C86803240 @default.
• W2046580842 hasIssue "6" @default.
• W2046580842 hasLocation W20465808421 @default.
• W2046580842 hasLocation W20465808422 @default.
• W2046580842 hasOpenAccess W2046580842 @default.
• W2046580842 hasPrimaryLocation W20465808421 @default.
• W2046580842 hasRelatedWork W1501253762 @default.
• W2046580842 hasRelatedWork W2030119528 @default.
• W2046580842 hasRelatedWork W2086764801 @default.
• W2046580842 hasRelatedWork W2137098232 @default.
• W2046580842 hasRelatedWork W2384227516 @default.
• W2046580842 hasRelatedWork W2386964570 @default.
• W2046580842 hasRelatedWork W2388926849 @default.
• W2046580842 hasRelatedWork W2413919837 @default.
• W2046580842 hasRelatedWork W2464686710 @default.
• W2046580842 hasRelatedWork W3153885336 @default.
• W2046580842 hasVolume "76" @default.
• W2046580842 isParatext "false" @default.

• next