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- W2046586516 abstract "Dysregulation in transforming growth factor (TGF)‐β1 signalling pathways has been linked to cancer. To study the association between single nucleotide polymorphisms (SNPs) of the TGF‐β1 gene and mycosis fungoides (MF). Using restriction fragment length polymorphism analysis, SNPs in the TGF‐β1 gene were studied in 55 patients with MF of different stages and in 100 apparently healthy controls. A significant difference was found between patients and controls in distribution of the different TGF‐β1 genotypes, with mutant forms (T/C, T/T) encountered significantly more often in patients with MF (P < 0.001). The heterozygous genotype (T/C) was significantly associated with patch stage MF, whereas the homozygous genotype (T/T) was significantly associated with tumour stage (stage IIb) MF (P = 0.001), although this study included only a small number of these patients. Mutant TGF‐β1 genotypes are significantly associated with MF in Egyptian patients, with the homozygous genotype (T/T) having a stronger association with tumour stage (stage IIb)." @default.
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- W2046586516 date "2014-08-22" @default.
- W2046586516 modified "2023-10-15" @default.
- W2046586516 title "Transforming growth factor-β1 gene polymorphism in mycosis fungoides" @default.
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- W2046586516 doi "https://doi.org/10.1111/ced.12404" @default.
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