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- W2046593188 abstract "Epithelioid sarcoma (ES) is a rare, aggressive soft tissue tumor with a characteristic predilection for adolescents and young adults, and a tendency to occur on distal extremities. We report a case of ES arising in an 80‐year‐old woman within a burn scar that histopathologically showed unusual ‘angiomatoid’ features. The patient presented initially with a solitary nodule on her right wrist arising at the site of a burn scar. Histopathologically, the tumor was composed of a proliferation of relatively bland, epithelioid and spindle cells focally arranged in a nodular pattern around areas of ‘geographic’ necrosis. In addition, there were prominent foci of hemorrhage and blood‐filled spaces as well as tumor cells with intracytoplasmic vacuoles, features suggestive of an angiomatous process. Immunohistochemistry showed positivity of tumor cells for cytokeratins and epithelial membrane antigen (EMA) whereas all vascular markers tested were negative. The overall histopathologic features were consistent with a diagnosis of ES. Follow up showed multiple recurrences arising proximally along the right upper extremity. Our case underlines the clinical and histopathological heterogeneity of ES, emphasizing the unusual occurrence of ES with ‘angiomatoid’ features in the elderly. In this uncommon setting, this tumor should be especially distinguished from epithelioid hemangioendothelioma and epithelioid angiosarcoma. The significance of development of ES on a healed burn scar is uncertain, but may suggest a possible causal relationship." @default.
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- W2046593188 date "2007-10-01" @default.
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- W2046593188 title "Epithelioid sarcoma with angiomatoid features: report of an unusual case arising in an elderly patient within a burn scar" @default.
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- W2046593188 doi "https://doi.org/10.1111/j.1600-0560.2007.00802.x" @default.
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