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• W2046602878 abstract "Prion protein gene (PRNP) polymorphisms are involved in modulating the appearance of atypical/Nor98 scrapie in sheep, with the alleles AHQ and AF141RQ strongly associated with occurrence of the disease. The presence of histidine at codon 154 has also been detected in Nor98-affected goats, but statistical analysis of the association between Nor98 and goat PRNP polymorphisms has not been reported previously. Here, a case-control study was carried out on eight Nor98-positive goats and 246 negative herdmates belonging to eight Italian Nor98 scrapie outbreaks. The results revealed that histidine at codon 154 is also strongly associated with the disease in goats." @default.
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• W2046602878 date "2008-12-01" @default.
• W2046602878 modified "2023-10-14" @default.
• W2046602878 title "Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats" @default.
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• W2046602878 doi "https://doi.org/10.1099/vir.0.2008/004150-0" @default.
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