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- W2046605515 abstract "HIV-1 envelope glycoprotein (gp120), as a CD4-binding reactant, has been shown to inhibit in its native form human T cell responses to several antigens. Here we show that gp120 in soluble form also inhibits activation of a specific human T cell line that responds to gp120-pulsed autologous antigen-presenting cells. In addition the inhibitory property of gp120 for antigen-driven T cell proliferation depends upon its ability to bind CD4 and is lost when CD4-binding capacity is abolished by denaturation, or blocked by complexing with soluble CD4 or with polyclonal antibodies. In contrast, antigenicity of denatured or complexed gp120 for specific human T cells is preserved. Similar effects are also observed with another CD4-binding reactant (i.e. anti-Leu 3a MoAb), which stimulates and/or inhibits human T cells specific for mouse immunoglobulins depending on native or denatured conformation." @default.
- W2046605515 created "2016-06-24" @default.
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- W2046605515 date "1992-04-01" @default.
- W2046605515 modified "2023-09-27" @default.
- W2046605515 title "Inhibitory activity of HIV envelope gp120 dominates over its antigenicity for human T cells" @default.
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- W2046605515 doi "https://doi.org/10.1111/j.1365-2249.1992.tb03032.x" @default.
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