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- W2046606543 abstract "BACKGROUND MIB-1, a murine monoclonal antibody, recognizes the Ki-67 antigen of routinely processed paraffin sections after microwave treatment. Cycling cells are positive for MIB-1 in their nucleus, and quiescent cells are negative for MIB-1. The MIB-1 labeling index represents the growth fraction of the cell population. METHODS A total of 150 cervical biopsy specimens were taken from 75 consecutive patients with cervical squamous cell carcinomas before radiotherapy (RT) and at 9 grays (Gy) of RT and were investigated to analyze the correlation between the MIB-1 labeling index or the δMIB-1 labeling index and patient prognosis or local disease control. The δMIB-1 index was calculated as the MIB-1 index at 9 Gy minus the MIB-1 index before RT. RESULTS The mean MIB-1 index was 38% (range, 11–67%) before RT and 54% (range, 15–85%) at 9 Gy. The MIB-1 index at 9 Gy was related to prognosis, including overall survival (P = 0.025), disease free survival (P = 0.024), and metastasis free survival (P = 0.045). Patients who had a δMIB-1 index > 20% showed a trend toward a higher disease free survival rate compared with patients who had a δMIB-1 index < 20% (P = 0.093). Neither the MIB-1 index nor the δMIB-1 index was associated with local disease control. CONCLUSIONS The high growth fraction at 9 Gy is regarded as a predictive factor for a good prognosis in patients with cervical squamous cell carcinoma patients who undergo RT alone. Cancer 2000;89:1526–31. © 2000 American Cancer Society." @default.
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- W2046606543 date "2000-10-01" @default.
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- W2046606543 title "High growth fraction at 9 grays of radiotherapy is associated with a good prognosis for patients with cervical squamous cell carcinoma" @default.
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- W2046606543 doi "https://doi.org/10.1002/1097-0142(20001001)89:7<1526::aid-cncr16>3.0.co;2-2" @default.
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