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• W2046606987 endingPage "1768" @default.
• W2046606987 startingPage "1757" @default.
• W2046606987 abstract "Abstract Mcm proteins are an important family of evolutionarily conserved helicases required for DNA replication in eukaryotes. The eukaryotic Mcm complex consists of six paralogs that form a heterohexameric ring. Because the intact Mcm2-7 hexamer is inactive in vitro, it has been difficult to determine the precise function of the different subunits. The solved atomic structure of an archaeal minichromosome maintenance (MCM) homolog provides insight into the function of eukaryotic Mcm proteins. The N-terminal positively charged central channel in the archaeal molecule consists of β-hairpin domains essential for DNA binding in vitro. Eukaryotic Mcm proteins also have β-hairpin domains, but their function is unknown. With the archaeal atomic structure as a guide, yeast molecular genetics was used to query the function of the β-hairpin domains in vivo. A yeast mcm5 mutant with β-hairpin mutations displays defects in the G1/S transition of the cell cycle, the initiation phase of DNA replication, and in the binding of the entire Mcm2-7 complex to replication origins. A similar mcm4 mutation is synthetically lethal with the mcm5 mutation. Therefore, in addition to its known regulatory role, Mcm5 protein has a positive role in origin binding, which requires coordination by all six Mcm2-7 subunits in the hexamer." @default.
• W2046606987 created "2016-06-24" @default.
• W2046606987 creator A5003495385 @default.
• W2046606987 creator A5004601851 @default.
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• W2046606987 date "2008-08-01" @default.
• W2046606987 modified "2023-10-05" @default.
• W2046606987 title "Functional Conservation of β-Hairpin DNA Binding Domains in the Mcm Protein of <i>Methanobacterium thermoautotrophicum</i> and the Mcm5 protein of <i>Saccharomyces cerevisiae</i>" @default.
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• W2046606987 doi "https://doi.org/10.1534/genetics.108.088690" @default.
• W2046606987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2516056" @default.
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• W2046606987 hasPublicationYear "2008" @default.
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