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- W2046607446 abstract "Morphine and enkephalin were applied to myenteric neurons of the guinea pig ileum while recording membrane potential with intracellular electrodes. Both opioids caused a concentration-dependent (1 nM–1 μM) hyperpolarization. The hyperpolarization was usually associated with a fall in input resistance, and it reversed to a depolarization when the cell membrane was held more negative than −100 mV. The amplitude of the hyperpolarization caused by a given concentration of morphine or enkephalin was dependent on the extracellular potassium ion concentration. The amplitude of the hyperpolarization and the conductance increase were inversely dependent on the extracellular calcium ion concentration. The results indicate that opiates activate the resting potassium conductance of myenteric neurons, especially when extracellular calcium concentration is low." @default.
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- W2046607446 title "Opiate activation of potassium conductance in myenteric neurons: inhibition by calcium ion" @default.
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- W2046607446 doi "https://doi.org/10.1016/0006-8993(82)90504-2" @default.
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